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Metabolic Acidosis Symptoms

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Metabolic Acidosis Due To Paracetamol (acetaminophen)

Summarized from McGregor A, Laight N, Nolan S. Paracetamol and high anion gap metabolic acidosis. J Intensive Care Society 2012; 13: 54-56 Armenian P, Gerona R, Blanc P et al. 5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use. J Emerg Med 2012; 43: 54-57 Metabolic acidosis is a common metabolic disturbance among the acutely/critically ill that has many possible causes. The condition is diagnosed by arterial blood gas analysis which reveals primary reduction in pH and bicarbonate, followed by secondary (compensatory) reduction in pCO2. Abnormal accumulation of endogenous organic acids is one broad mechanism that gives rise to metabolic acidosis, which is differentiated from other mechanisms by being associated with high anion gap. The most common endogenous organic acid metabolic acidosis are: lactic acidosis (accumulation of lactic acid) and ketoacidosis (accumulation of ketoacids). Rarer causes of high anion gap metabolic acidosis due to organic acid accumulation are those that result from ingestion of a toxic substance whose metabolism involves production of an organic acid. For example, the toxicity of ethylene glycol is due in par Continue reading >>

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Popular Questions

  1. takecare0904

    Hi. As the title says, I'm losing my hair. I've been on keto (mostly lazy) since May and have lost 25lbs... but I've recently started losing my hair, too. Any ideas? Thanks!

  2. Amesicle

    Hair loss can be a symptom of hypothyroidism. Keto can mess with your thyroid function. Have a doctor check your thyroid levels. Insist on having T4, T3, TSH, and FT4 checked, not just TSH.
    Your FT4 must be in the upper half of "normal" range of values for you to feel OK and take away the symptoms (e.g. Hair loss).

  3. takecare0904

    Thanks. I'll check it out!

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