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Effect Of Topiramate On Acidbase Balance: Extent, Mechanism And Effects

Effect of topiramate on acidbase balance: extent, mechanism and effects 1Departments of Pharmacology, The University of Liverpool, Liverpool, UK 2Departments of Neurological Sciences, The University of Liverpool, Liverpool, UK 1Departments of Pharmacology, The University of Liverpool, Liverpool, UK 2Departments of Neurological Sciences, The University of Liverpool, Liverpool, UK Professor Munir Pirmohamed, Department of Pharmacology, The University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. Tel: + 44 151 794 5549 Fax: + 44 151 794 5540 E-mail: [email protected] Received 2009 Apr 2; Accepted 2009 Jul 27. Copyright Journal compilation 2009 The British Pharmacological Society This article has been cited by other articles in PMC. Topiramate is licensed for the treatment of epilepsy and for migraine prophylaxis, but is also used off-licence for a wide range of indications. With the increasing use of topiramate, reports have emerged that topiramate can cause metabolic acidosis in some patients. It does this by impairing both the normal reabsorption of filtered HCO3 by the proximal renal tubule and the excretion of H+ by the distal renal tubule. This combination of defects is ter Continue reading >>

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  1. Import

    Anyone follow a low carb diet for an extended time and experience ED? I've been on some sort of low carb diet for about 2 yrs now and its been a serious problem. I'm only 21 and am prone to this problem to begin with, but it hasn't been too bad, a problem here and there. But with low carbs sometimes I cant get it or keep it up, which is scary since I sometimes use Viagra and i'm only 21. I know for a 2 week period I took a break and ate carbs I started having morning erections, which now I dont. Well, Trying to get ripped, maybe if I try 60%prot, 30%fat and 20%carbs, especially post-workout that would help. Doing Bev Int type diet of 60%prot, 30%fat and 10%carbs from vegetables. Anyway, anyone else have this problem with low carb diets? If so, how did you remedy the problem. Also, is there any direct correlation between carbs and erections, or am I just screwed either way?

  2. Import

    You're not by any chance taking an ephedra-like product while you're on this low carb diet are you? Some fat burners that contain such compounds cause ED in some men. Never happened to me, of course, uh uh, no way.....

  3. Import

    I have an idea, eat carbs, you do not have to eat low carbs to get ripped. I don't know of any correlation between the two, but if you eat carbs and you can perform then the low carb diet is not for you. It is a DIET for quick weight loss it is not intented for long use.

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