Compensatory Hypoventilation In Metabolic Alkalosis.
Compensatory hypoventilation in metabolic alkalosis. Although hyperventilation is a well-known compensatory mechanism in metabolicacidosis, compensatory hypoventilation has been inconsistent and controversial inmetabolic alkalosis. Six healthy subjects were studied under baseline conditions and during steady-state metabolic acidosis (seven episodes) and alkalosis (14episodes). Minute ventilation (VE) fell in metabolic alkalosis and rose inmetabolic acidosis. These changes in ventilation were entirely due to reductionand elevation of tidal volume (VT) respectively, while respiratory frequency (f) remained unchanged. Alveolar ventilation fell during metabolic alkalosis andresulted in elevation of arterial PCO2 in all subjects. The ventilatory response to arterial PCO2 in all subjects. The ventilatory response to CO2 breathing wasalso diminished. There was a linear relationship between PaCO2 and plasma [HCO-3]in metabolic acidosis and alkalosis which was defined as PaCO2 (mm Hg = 0.7[HCO-a] + 20 (+/- SEM), r = 0.95. Although arterial PO2 and plasma [K+] fellduring metabolic alkalosis, minute ventilation did not change upon breathingoxygen and there was no correlation between changes Continue reading >>