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Long Term Complications Of Dka

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The Outcome Of Brittle Type 1 Diabetes—a 20 Year Study

Aims: To determine the long-term (20 years from presentation) outcome of brittle type 1 diabetes characterized by recurrent episodes of ketoacidosis (DKA). Methods: The cohort studied was a group of brittle diabetic patients from various parts of UK originally identified between 1979 and 1985. Patients were traced, where possible, via their diabetic clinics and/or general practitioners. Data on survival or otherwise were obtained from hospital case notes and information from diabetes care team members. For survivors, clinical and demographic information obtained included complication status and whether they still had brittle characteristics. They were also compared with a matched case–control group of type 1 patients with no history of brittle behaviour. Results: The original cohort comprised 33 patients— all female and mean ± SD, aged 18 ± 5 years and diabetes duration 8 ± 4 years. Thirteen were not traceable and 10 of the remaining 20 (50%) had died during the mean 22 years of follow-up. Deaths occurred evenly throughout the period, and causes were chronic renal failure (3), DKA (3), hypoglycaemia (2), subarachnoid haemorrhage (1) and uncertain (1). Age at death ranged fro Continue reading >>

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Popular Questions

  1. Christopher

    In another thread someone made the statement that kids who have DKA at dx are at "great risk for complications down the road". It was also said that those who have "profound" DKA at dx have more difficulty with blood glucose control.
    I have not heard this before and would like to see any studies that discuss these issues, or hear anecdotal evidence from those parents who may (or may not) have experienced this.

  2. Dvbo79

    I would like to read a study on this as well. My son was in severe DKA when diagnosed. We are almost but not quite a year in. He doesn't appear to have a harder time than any other type 1 toddler. Very curious about this...

  3. obtainedmist

    This totally goes against what happened to us! DD came back from a 5 month exchange in Italy having lost 32 lbs and in big-time DKA! However, she has had a relatively easy time maintaining her bgs and good A1C's. I really do think that there are so many variations of this disease (YDMV) that this kind of generalization misses the mark!

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