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Lactic Acidosis

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Lactic Acidosis In Metformin-treated Patients. Prognostic Value Of Arterial Lactate Levels And Plasma Metformin Concentrations.

Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. Service d'Endocrinologie-Nutrition, Hpital Universitaire, Amiens, France. [email protected] The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis. However, because of lack of data, the prognostic significance of hyperlactataemia in metformin-treated patients is not known. Data were collected from 49 metformin-treated patients with lactic acidosis (arterial lactate level > or = 5 mmol/L and blood pH < or = 7.35) and available plasma metformin concentration data to investigate the association of arterial lactate levels and plasma metformin concentrations with mortality. The overall mortality rate in this patients sample was 45% and the median arterial lactate level was 13.1 mmol/L. Median lactate levels were similar in patients who survived (13 mmol/L) and those who died (14.3 mmol/L), whereas the median plasma metformin concentration was 3 times higher in patients who survived (20.6 mg/L versus 6.3 mg/L). In this, the largest series of metformin-treated patients with Continue reading >>

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Popular Questions

  1. lenasvn

    Any idea what can be the reason for the lab results? The nurse called me and told me I had ketones in my urine. The glucose (fasting) was normal. It can be a sign of starvation or alcoholism too (alcoholism excluded,,,,LOL! can't tolerate even one beer). I eat frequent meals (well, cheat once in a while!) and take adquate vitamins. He want me to do a stool test (sorry about the graphics) to look for blood in stool. I don't have to go into details, but gramdma passed at age 43 from colon/ stomac cancer. it started with polyps in late teens- just like with me, besides my IBS since, well, since diapers!
    Anywho, any input on this Ketone deal, anyone had it and it was NOT diabetes? I also had anemia, despite my food and vitamin intake. This CAN be caused by RA (which in my case is not in control as I would want it), as well as many other things. I am ready for whatever, so blast your thoughts.

  2. futurehope

    Did you have a dipstick test done?
    Over the past 4 months I have had Keotones in my Urine and the only information I get is that this can be a sign of starvation.
    Are you on any medications? I am beginning to blame this one on my antidepressants as I have taken it on two different occassions over the past 4 years and I had EXCESSIVE weight loss both times. My appetite is not too good either. The first time I stopped the medication the weight VERY SLOWLY started to come back.
    Why would he want a stool test (just because of the keotones)?
    I have also heard that those urine dip tests can read inaccurate sometimes.
    Hope this helps, but I do not have any concrete answers either.

  3. lenasvn

    I don't know if they use dipstick in hospital labs. I think it would only be reasonable to run stool test if you present with both anemia and ketones at the same time, as well as severe malaise, and a family history of colon cancer. I was just hoping there might be some typical signs of CFS, since we're so toxic?

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