Ketone Bodies Synthesis

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Ketogenesis pathway. The three ketone bodies (acetoacetate, acetone, and beta-hydroxy-butyrate) are marked within an orange box Ketogenesis is the biochemical process by which organisms produce a group of substances collectively known as ketone bodies by the breakdown of fatty acids and ketogenic amino acids.[1][2] This process supplies energy to certain organs (particularly the brain) under circumstances such as fasting, but insufficient ketogenesis can cause hypoglycemia and excessive production of ketone bodies leads to a dangerous state known as ketoacidosis.[3] Production[edit] Ketone bodies are produced mainly in the mitochondria of liver cells, and synthesis can occur in response to an unavailability of blood glucose, such as during fasting.[3] Other cells are capable of carrying out ketogenesis, but they are not as effective at doing so.[4] Ketogenesis occurs constantly in a healthy individual.[5] Ketogenesis takes place in the setting of low glucose levels in the blood, after exhaustion of other cellular carbohydrate stores, such as glycogen.[citation needed] It can also take place when there is insufficient insulin (e.g. in type 1 (but not 2) diabetes), particularly durin Continue reading >>

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Popular Questions

  1. Jeanwf

    Hi. Anyone out there suffer from feeling really, really hot doing Keto Diet. My face is as red as beetroot in the mornings and throughout the day I get several hot flushes. Any ideas?:explode:

  2. rachelrb85

    Could it be menopause?

  3. Jeanwf

    I have finished now with the menopause as I started when I was 46! Grrrrr. Could it be because I am burning fat?

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