Share on facebook

Ketone Body Metabolism

Ketone body metabolism includes ketone body synthesis (ketogenesis) and breakdown (ketolysis). When the body goes from the fed to the fasted state the liver switches from an organ of carbohydrate utilization and fatty acid synthesis to one of fatty acid oxidation and ketone body production. This metabolic switch is amplified in uncontrolled diabetes. In these states the fat-derived energy (ketone bodies) generated in the liver enter the blood stream and are used by other organs, such as the brain, heart, kidney cortex and skeletal muscle. Ketone bodies are particularly important for the brain which has no other substantial non-glucose-derived energy source. The two main ketone bodies are acetoacetate (AcAc) and 3-hydroxybutyrate (3HB) also referred to as β-hydroxybutyrate, with acetone the third, and least abundant. Ketone bodies are always present in the blood and their levels increase during fasting and prolonged exercise. After an over-night fast, ketone bodies supply 2–6% of the body's energy requirements, while they supply 30–40% of the energy needs after a 3-day fast. When they build up in the blood they spill over into the urine. The presence of elevated ketone bodies i Continue reading >>

Share on facebook

Popular Questions

  1. Thumbelina

    I'm not much of a water drinker but reading about it here has convinced me I need to up my intake. I went from drinking about 3 glasses a day to at least 64 oz. now. Before I upped my water intake, my Ketostix were showing moderate levels of ketones (usually 15 to 40 mg/dl). I've been drinking 64+ oz of water for three days now, and today when I used the Ketostix it showed that I was not in ketosis (no color change). I have not changed my diet, which is between 20-25 net carbs per day. I have noticed, however, that my urine is much more dilute than before. Does drinking lots of water affect (1) the results on the Ketostix strips and (2) ketosis itself???
    Thanks so much!

  2. adkpam

    Yes, it affects the Ketostix, and no, it doesn't harm ketosis. The more water you drink, the more weight you lose; almost anyone has had that experience.
    Try checking first thing in the morning. But you can be in ketosis and not see the change; I never used the Ketostix.

  3. LadyBelle

    The reason your sticks show lighter is your urine is less concentrated. The color of the ketosticks isn't important. If they are even a little pink, then you are in ketosis. It's like saying, well my pregnancy test wasn't that dar, myabe I'm only kind of pregnant I'd better shoot for more pregnant

  4. -> Continue reading
read more close

Related Articles

  • Ketolysis

    Test description The Invitae Ketolysis Disorders Panel analyzes 2 genes, ACAT1 and OXCT1, which are associated with disorders of impaired ketone body metabolism. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Additionally, identification of disease-causing variants provides accurate genetic counseling, recognition of at-risk family members and assessment of carrier status. ...

    ketosis Jan 5, 2018

More in ketosis