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Ketoacidosis Pathophysiology

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Ketoacidosis Pathophysiology

Introduction Diabetic ketoacidosis Diabetic ketoacidosis is a serious, life threatening condition - successful treatment requires attention to metabolic consequences. Ketone production In the normal animal free fatty acids (FFA) are released from adipose tissue in the process of lipolysis and are used as fuel or assimilated by the liver in the presence of reduced insulin concentrations and increased glucagon concentrations. They are used to build triglycerides, metabolized in the tricarboxylic acid cycle or converted to ketone bodies. In the face of a relative or absolute insulin deficiency the cells are unable to uptake and utilize glucose. Ketone bodies can be used by peripheral tissues and the liver as an alternative source of energy and are therefore life-saving in the short-term. Production is normally carefully controlled by a homeostatic mechanism. If this balance is disturbed a number of processes are activated which together produce a decompensated state which inevitably progresses towards death unless averting action is taken. As the rate of ketone body production begins to exceed the rate at which they can be used, ketonemia develops with associated acidosis. Once the co Continue reading >>

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Popular Questions

  1. tina

    Hi,
    can you gain weight if you are in ketosis?

  2. Linda

    Tina, if you've gained weight it's unlikely you've gained bodyfat. The scale doesn't just measure fat but also bone, muscle, water weight etc and also fluctuates due to hormones, food & drinks consumed and many other factors. If you're in ketosis and eating TOO much fat then you could be burning primarily dietary fat but this isn't necessarily the case and doesn't mean you'll have to cut back on fat. Post what you're eating, how much have you gained and in what period? Remember the scale can fluctuate a few lbs even during the course of one day!

  3. Ellen

    You can gain weight in ketosis if you eat too many calories. Ketosis just means that you're burning fat for fuel. If you have more calories than you burn you will gain weight.

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