Ketoacidosis Pathophysiology

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Chapter 220. Diabetic Ketoacidosis

Diabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus. The incidence and prevalence of diabetes are rising; as of 2005, an estimated 7% of the U.S. population had diabetes. In patients age 60 or older, the prevalence is estimated to be 20.9%.1 DKA occurs predominately in patients with type 1 (insulin-dependent) diabetes mellitus, but unprovoked DKA can occur in newly diagnosed type 2 (non–insulin-dependent) diabetes mellitus, especially in blacks and Hispanics.2 Between 1993 and 2003, the yearly rate of ED visits for DKA per 10,000 U.S. population with diabetes was 64, with a trend toward an increased rate of visits among the black population compared with the white population.3 Europe has a comparable incidence. A better understanding of pathophysiology and an aggressive, uniform approach to diagnosis and management have reduced mortality to <5% of reported episodes in experienced centers.4 However, mortality is higher in the elderly due to underlying renal disease or coexisting infection and in the presence of coma or hypotension. DKA is a response to cellular starvation brought on by relative insulin deficiency and counterregulatory or cat Continue reading >>

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Popular Questions

  1. Eadem298

    Hey, how much have you lot on a strict low carb diet? Like Atkins or ketogenic diet in general...
    Avoiding carbs and sugar like fruits and simple carbs.
    Just curious. For me worked a lot and for you?

  2. til_then

    This time around,23 pounds. It has taken a while though. About 3 months. But I'm older and have a really slow metabolism.

  3. maexoxchloe

    Keto diet is pretty effective if your willing to never eat a fruit and majority of veggies ever again. Also if you like swimming in grease and fat.
    I think I lost about 10-15 in a month. If you think about it, that's doable on a 'normal' diet. It's a pretty expensive diet because you eat loads of meat, cheese, and grease. You will get constipated af.
    In my experience, not worth it. All the veggies out of my garden rotted in my fridge because I couldn't eat them.
    But you got to make that decision yourself. Myfitnesspal has Keto sub groups you could learn a lot on there from 'non-disordered' people.

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