Ketoacidosis Combining Form

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Clinical Applications Of Diabetes Antibody Testing

Context: Autoantibodies to glutamate decarboxylase, islet antigen-2, insulin, and zinc transporter-8 are characteristic of type 1 diabetes. They are detectable before clinical onset and define the subgroup of patients with latent autoimmune diabetes in adults. Autoantibody assays are increasingly available to clinicians. This article reviews the prognostic significance of autoantibodies and considers the utility of diabetes antibody testing in routine clinical practice. Evidence Acquisition: The medical literature to May 2009 was reviewed for key articles and consensus statements covering use of islet autoantibody testing for prediction and classification of diabetes and implications for therapy. Evidence Synthesis: Sensitive and specific glutamate decarboxylase and islet antigen-2 antibody assays are widely available, although to insulin autoantibody assays remain variable. Islet autoantibodies appear early in life, and testing for multiple antibodies identifies unaffected individuals at very high risk of type 1 diabetes with high sensitivity. This is important for research, but currently no intervention prevents or delays diabetes, and evidence of benefit from awareness of risk i Continue reading >>

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Popular Questions

  1. mommyx4

    Wanted to know if it was ok to have watermelon while in the induction phase. We bought 2 big ones right before we (dh & I ) deceided to try atkins. I looked on the atkins web site in the carbgramcounter and it has almost no carbs, .2 for .25 cup if I remember right. If it is,i remember reading something about it, is it because of the sugar?

  2. Pandora23

    All fruits are a no no during induction. According to fitday 1/2 cup of diced watermelon contains 5 carbs.

  3. LisaAC

    If I remember right, watermelon is definitely a no no due to the high sugar content. I know I miss it. I used to love watermelon.

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