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Ketoacidosis Can Result In

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high blood sugar, low blood pH, and ketoacids in either the blood or urine. The primary treatment of DKA is with intravenous fluids and insulin. Depending on the severity, insulin may be given intravenously or by injection under the skin. Usually potassium is also needed to prevent the development of low blood potassium. Throughout treatment blood sugar and potassium levels should be regularly checked. Antibiotics may be required in those with an underlying infection. In those with severely low blood pH, sodium bicarbonate may be given; however, its use is of unclear benefit and typically not recommended. Rates of DKA vary around the world. About 4% of people with type 1 diabetes in United Kingdom develop DKA a year, while in Malaysia the condition affects about 25% a year. DKA was first described in 1886 and, until the introduction of insulin therapy in the 1920s, it was almost universally fatal. The risk of death with adequate and timely treatment is currently around 1–4%. Up to 1% of children with DKA develop a complication known as cerebral edema. The symptoms of an episode of diabetic ketoacidosis usually evolve over a period of about 24 hours. Predominant symptoms are nausea and vomiting, pronounced thirst, excessive urine production and abdominal pain that may be severe. Those who measure their glucose levels themselves may notice hyperglycemia (high blood sugar levels). In severe DKA, breathing becomes labored and of a deep, gasping character (a state referred to as "Kussmaul respiration"). The abdomen may be tender to the point that an acute abdomen may be suspected, such as acute pancreatitis, appendicitis or gastrointestinal perforation. Coffee ground vomiting (vomiting of altered blood) occurs in a minority of people; this tends to originate from erosion of the esophagus. In severe DKA, there may be confusion, lethargy, stupor or even coma (a marked decrease in the level of consciousness). On physical examination there is usually clinical evidence of dehydration, such as a dry mouth and decreased skin turgor. If the dehydration is profound enough to cause a decrease in the circulating blood volume, tachycardia (a fast heart rate) and low blood pressure may be observed. Often, a "ketotic" odor is present, which is often described as "fruity", often compared to the smell of pear drops whose scent is a ketone. If Kussmaul respiration is present, this is reflected in an increased respiratory rate.....

Severe Hypoglycemia And Diabetic Ketoacidosis In Adults With Type 1 Diabetes: Results From The T1d Exchange Clinic Registry

Severe Hypoglycemia and Diabetic Ketoacidosis in Adults With Type 1 Diabetes: Results From the T1D Exchange Clinic Registry State University of New York Upstate Medical University (R.S.W.), Syracuse, New York 13210 Search for other works by this author on: Jaeb Center for Health Research (D.X., S.N.D., K.M.M., R.W.B.), Tampa, Florida 33647 Search for other works by this author on: Barbara Davis Center for Childhood Diabetes (D.M.M., A.M.), Aurora, Colorado 80045 Search for other works by this author on: Barbara Davis Center for Childhood Diabetes (D.M.M., A.M.), Aurora, Colorado 80045 Search for other works by this author on: University of Pennsylvania School of Medicine (M.R.R.), Philadelphia, Pennsylvania 19104 Search for other works by this author on: Keck School of Medicine of the University of Southern California (A.L.P.), Los Angeles, California 90211 Search for other works by this author on: International Diabetes Center Park Nicollet (R.M.B.), Stanford, California 55416 Search for other works by this author on: Minneapolis, Minnesota; and Stanford University (B.H.), Stanford, California 55416 Search for other works by this author on: Jaeb Center for Health Research (D.X., Continue reading >>

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  1. ab.er.rant

    I just came back from a series of test to check my heart palpitations. The doctor didn't see anything obvious that could directly cause palpitations, so the implication seems to be that it's more related to my diet change (been a month since I started moderate low-carb) and bodily adjustments.
    My blood test came back a bit high on uric acid, and the doctor said a low-carb diet has a tendency to cause it. So essentially I'm told that I'm at a risk of developing high blood pressure. I wasn't diagnosed as having gout since I have no joint problems. The doctor also suggested that I could simply be not eating enough, causing elevated levels.
    Anyone has a similar experience? It seems that I should eat less meat and more veges.

  2. muzza3

    Hi @ab.er.rant
    Can't help personally but was interested so had a look. This seemed credible and had some suggestions.
    http://www.naturalremedies.org/uric-acid/
    Cheers

  3. chri5

    ab.er.rant said: ↑
    I just came back from a series of test to check my heart palpitations. The doctor didn't see anything obvious that could directly cause palpitations, so the implication seems to be that it's more related to my diet change (been a month since I started moderate low-carb) and bodily adjustments.
    My blood test came back a bit high on uric acid, and the doctor said a low-carb diet has a tendency to cause it. So essentially I'm told that I'm at a risk of developing high blood pressure. I wasn't diagnosed as having gout since I have no joint problems. The doctor also suggested that I could simply be not eating enough, causing elevated levels.
    Anyone has a similar experience? It seems that I should eat less meat and more veges.
    Click to expand... Hi, if I was you I would make sure you are drinking plenty of water as this helps to flush uric acid. I used to be prone to gout attacks but since going lchf I haven`t had one in well over a year so I am a little sceptical of lchf causing high uric acid levels. Best of luck anyway, Chris.

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What is KETOACIDOSIS? What does KETOACIDOSIS mean? KETOACIDOSIS meaning - KETOACIDOSIS definition - KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Ketoacidosis is a metabolic state associated with high concentrations of ketone bodies, formed by the breakdown of fatty acids and the deamination of amino acids. The two common ketones produced in humans are acetoacetic acid and ß-hydroxybutyrate. Ketoacidosis is a pathological metabolic state marked by extreme and uncontrolled ketosis. In ketoacidosis, the body fails to adequately regulate ketone production causing such a severe accumulation of keto acids that the pH of the blood is substantially decreased. In extreme cases ketoacidosis can be fatal. Ketoacidosis is most common in untreated type 1 diabetes mellitus, when the liver breaks down fat and proteins in response to a perceived need for respiratory substrate. Prolonged alcoholism may lead to alcoholic ketoacidosis. Ketoacidosis can be smelled on a person's breath. This is due to acetone, a direct by-product of the spontaneous decomposition of acetoacetic acid. It is often described as smelling like fruit or nail polish remover. Ketosis may also smell, but the odor is usually more subtle due to lower concentrations of acetone. Treatment consists most simply of correcting blood sugar and insulin levels, which will halt ketone production. If the severity of the case warrants more aggressive measures, intravenous sodium bicarbonate infusion can be given to raise blood pH back to an acceptable range. However, serious caution must be exercised with IV sodium bicarbonate to avoid the risk of equally life-threatening hypernatremia. Three common causes of ketoacidosis are alcohol, starvation, and diabetes, resulting in alcoholic ketoacidosis, starvation ketoacidosis, and diabetic ketoacidosis respectively. In diabetic ketoacidosis, a high concentration of ketone bodies is usually accompanied by insulin deficiency, hyperglycemia, and dehydration. Particularly in type 1 diabetics the lack of insulin in the bloodstream prevents glucose absorption, thereby inhibiting the production of oxaloacetate (a crucial molecule for processing Acetyl-CoA, the product of beta-oxidation of fatty acids, in the Krebs cycle) through reduced levels of pyruvate (a byproduct of glycolysis), and can cause unchecked ketone body production (through fatty acid metabolism) potentially leading to dangerous glucose and ketone levels in the blood. Hyperglycemia results in glucose overloading the kidneys and spilling into the urine (transport maximum for glucose is exceeded). Dehydration results following the osmotic movement of water into urine (Osmotic diuresis), exacerbating the acidosis. In alcoholic ketoacidosis, alcohol causes dehydration and blocks the first step of gluconeogenesis by depleting oxaloacetate. The body is unable to synthesize enough glucose to meet its needs, thus creating an energy crisis resulting in fatty acid metabolism, and ketone body formation.

Diabetes And Ketoacidosis

Diabetic ketoacidosis (DKA)is a medical emergencycaused high blood glucose levels ( hyperglycaemia ). Ketoacidosis is caused by a lack of insulin to process glucose to use as energy. The body responds by using fat stores for energy instead, releasing damaging ketones into the blood as a by-product. The symptoms of DKA include excessive thirst, nausea or vomiting , dry skin , blurred vision , and rapidbreathing. Without treatment, dehydration is a risk to health. High ketone levels can often be smelled on the breath of a person with DKA, with a nail varnish or pear-drop type aroma. A related condition is a hyperosmolar hyperglycaemic state, HHS, previously known as HONK: hyperglycaemic hyperosmolar non-ketotic coma. In this condition, high blood glucose levels cause similar symptoms as DKA, but without the ketones release. Treatment of ketoacidosis requires insulin and fluids as recommended by your doctor. He or she may suggest that you increase the dose of your insulin or change your insulin type to a short-acting form. Your doctor will also suggest you drink more fluids - sugar -free, of course. You will need to check your sugars frequently and repeat the assessment of your urine Continue reading >>

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  1. Markette

    Today I learned about ketosis.
    Yesterday, Day 15 for me, I had a lady doctor's appointment wherein they collected a urine sample. My ketones were sky high and prompted my doctor -- who I had never seen before -- to tell me he didn't think I was eating well. I laughed, insisted that I eat quite well, and asked him to explain his concern more fully. He explained that ketones indicate I am passing fat, that I'm not eating well, starving. He insisted that I grab a fruit juice on the way home, push fluids the rest of the night, and follow up with my GP. Let me tell you, that much glucose at once felt weird, but who was I to argue with his quite insistent orders?
    After some Google-fu, I found out that that's not exactly what ketones are, or what high ketones in urine means, but close. They're a byproduct of my body burning fat for energy instead of glucose. They are a warning sign if you're a Type I diabetic (I'm not) or have liver issues (I don't know of any) and can be a tell-tale sign of anorexia or starvation or fasting (uh, no), but for folks on low-carb, high-fat diets, they more often indicate that your metabolism has shifted from processing glucose to processing fat for fuel.
    On top of the high ketone level in my urine, I felt terrible all day long. I couldn't sleep the night before, had another base-of-the-neck migraine-like headache, had the chills, and finally vomited around 3am. I chalked it up to the flu or the issue that had brought me to my doctor to begin with, but after further research, I'm wondering if I might actually be transitioning to a ketogenic metabolism and have a touch of the "ketosis flu".
    I'm not much of an athlete these days, and ketosis certainly isn't the goal of my Whole30. I did some quick research on this forum and saw that other ladies -- mainly pregnant ones -- had doctors who were concerned with high ketones while they were Whole30ing. They increased their caloric intake via more starches. So I also decided to tweak my diet even more this round and increase my starch (yams, bananas, squash, etc.) intake and see how I feel.
    I'm seeing my GP next week -- also for the first time -- and I'd like to be able to ask some pointed questions about the paleo diet and ketosis and ketoacidosis, as I'm sure another urinalysis will reveal the same high ketone levels and probably bring similar concerns. I've been strict paleo since 2011, am 114 pounds, 5'4", and have a very low body fat -- I'm not opposed to remaining in ketosis, but am concerned that I don't have a ton of fat on my frame to burn and want to monitor my diet and health responsibly.
    Has anyone else -- especially ladies -- had high ketone levels in their urine? Any precautions I should be aware of? Any tweaks to a Whole30 you'd recommend?

  2. Tina R

    This has been discussed on this forum http://forum.whole9life.com/topic/2737-why-is-nobody-talking-about-ketosis/. Here is a thread that might help. You can also search google "whole30 Ketosis" for other answers on the forum. Good Luck!

  3. kirkor

    Bonus ketosis! Lucky!
    Several of us are aiming for it here.

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What’s The Difference Between Ketosis And Diabetic Ketoacidosis?

Ketosis and ketoacidosis sound similar and are sometimes confused, but don’t mistake these conditions for one another. These involve two different sets of circumstances with considerably different outlooks. Both are triggered by an increase of ketones in the body, which are acids released into the bloodstream when the body burns fat for energy instead of carbohydrates. But it’s how the body responds to this increase that sets ketosis and ketoacidosis apart from each other. RELATED: How to Tell the Difference Between Good and Bad Carbs What Is Ketosis and How Does the Process Work? “Ketosis is a natural state that occurs when you start to metabolize fat instead of sugar,” says Michael Greenfield, MD, endocrinologist and chief medical officer at El Camino Hospital in Palo Alto, California. “It occurs often when people fast and use up the stores of sugar in their body." To understand ketosis, it helps to understand how the body burns energy. Carbohydrates and fat are both energy sources, and the body typically burns carbs (sugar or glucose) first, and then fat. If there aren’t enough carbohydrates in your system, it begins to break down fat for energy, which puts your body Continue reading >>

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  1. Elorah

    I've started doing my own urinalysis on my cats with UA strips. And there have been a few that had ketones show up just slightly or a little more. But glucose was negative. I don't know how to interpret these results given no glucose present. Can somebody tell me what this means so I know if there's something I need to be treating?

  2. Rebecca RVT

    Sometimes the color of urine can make some of the values a false positive. I've seen this with ketones and bilirubin.
    I don't find the strips useful when it comes to finding infection (the white blood cell value often gives me false negatives/false positives), any true concerns should be checked under a microscope.
    If you have any diabetic signs such as excess drinking/peeing, walking on their hocks, loss of appetite along with weight loss or cystitis/urinary tract infection (UTI's are very rare in cats) such as peeing around the house, crying at the litterbox, straining. That would deem a vet visit.

  3. mhwombat

    According to http://www.petmd.com/cat/conditions/endocrine/c_ct_diabetes_with_ketoacidosis, ketones are an emergency; you should go to your vet immediately.
    However... if it's only a slight amount, and there are no other symptoms, I think just a call to the vet will suffice.
    In either case, I suggest you ask your vet for some guidelines about what to do in future. The advice will probably be specific to your cat and the history of his diabetes management, and what readings are typical for your cat.

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