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Ketoacidosis Breath

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Breath Acetone Is A Reliable Indicator Of Ketosis In Adults Consuming Ketogenic Meals1,2,3

Abstract Background: Ketogenic diets are used therapeutically to treat intractable seizures. Clinically, it appears that the maintenance of ketosis is crucial to the efficacy of the diet in ameliorating seizures. To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed. Objective: The objective was to determine which index, breath acetone or urinary acetoacetate, is more strongly related to the plasma ketones acetoacetate and β-hydroxybutyrate. Design: After fasting overnight for 12 h, 12 healthy adults consumed 4 ketogenic meals over 12 h. Blood, breath, and urine samples were collected hourly. Blood was analyzed for plasma acetoacetate and β-hydroxybutyrate, breath for acetone, and urine for acetoacetate. Results: By the end of the 12-h dietary treatment, plasma acetoacetate, plasma β-hydroxybutyrate, and breath acetone had increased 3.5-fold, whereas urinary acetoacetate increased 13-fold when measured enzymatically and 25-fold when measured with urinary ketone dipsticks. Plasma acetoacetate was best predicted by breath acetone (R2 = 0.70, P < 0.0001). Plasma β- Continue reading >>

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Popular Questions

  1. treehorn+bunny

    You don't need to be in DKA to get ketosis. It's probably because he hasn't been eating enough/is sick. It is not uncommon for people who have stomach viruses to burn ketones.
    In nondiabetic persons, ketonuria may occur during acute illness or severe stress.

  2. PorcineWithMe

    GERD/reflux/"heartburn" can cause that smell and so can taking Prilosec (or other PPIs). My husband had THE WORST breath from taking Prilosec. Ugh.

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