Is Ketosis Bad For Your Brain

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Ketones Suppress Brain Glucose Consumption

Go to: 1. INTRODUCTION Neurodegeneration after oxidative stress limits the recovery of tissue response and appears to be caused by impaired glycolysis. If indeed there is a defect in glucose metabolism it might be beneficial to supplement energy metabolism with an alternate substrate. It was suggested that brain can supplement glucose as the principal energy substrate with ketone bodies1–3 without altering oxygen consumption4,5. Classic studies of ketosis induced by fasting or starvation in humans showed that brain function was maintained which was attributed to the utilization (oxidation) of ketone bodies as alternate energy substrates to glucose by the brain6. Rats that have been fasted for 2–3 days showed no difference in cerebral blood flow (CBF) or CMRO27. One mechanism by which ketosis might be beneficial is through the metabolic step where ketones enter the TCA cycle at the level of citrate bypassing glycolysis, the step after pyruvate dehydrogenase complex where the enzyme activity is often impaired. Through feed-back regulation, ketones are known to down regulate glycolytic rates at various levels such as citrate, phosphofructokinase and/or hexokinase. In addition, par Continue reading >>

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  1. gamacnei

    make sure you're weighing your food with a darn scale. At least twice a day someone posts about not being able to lose weight and then it's revealed they aren't weighing their food. I'm starting to feel bad for the people who have to respond to these posts 100 times a week with "are you weighing your food"? Just do it. Go buy a darn scale. Weigh your food. /endrant

  2. anbeav

    At least twice a day
    Conservative estimate...

  3. gamacnei

    You should count how many times a day for a week you post the exact same questions...do you keep a database of stock answers in microsoft word?

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