Infection Dka Pathophysiology

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2. Learning Objectives

4.1. Diabetic Ketoacidosis (DKA) Diabetic ketoacidosis results from lack of insulin and it is considered a medical emergency as it has a mortality rate of approximately 5 percent, mostly because of late recognition and frequently suboptimal management. Diabetic ketoacidosis can be the first manifestation of type 1 diabetes in a previously undiagnosed patient or can occur in a patient with type 1 diabetes when insulin requirements rise during medical stress. Noncompliance with insulin administration is another common cause of DKA. Although DKA is much more common in type 1 diabetes, it can also occur in patients with type 2 diabetes who have a predominant insulin secretory defect under severe medical stress. 4.1.1. Pathophysiology Diabetes is often referred to as "starvation in the midst of plenty" and the progression of events that results from acute insulin deficiency holds this concept to be valid. Insulin deficiency leads to impaired peripheral glucose uptake. In the presence of inadequate insulin, energy stores in fat and muscle are rapidly broken down into fatty acids and amino acids, which are then transported to the liver for conversion to glucose and ketones (beta-hydroxybu Continue reading >>

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Popular Questions

  1. FrankUnderWood

    I have started out for the third and final time on Keto on Monday.
    My weight has dropped 3 pounds in 4 days, but the Keto sticks are not changing colour (only started yesterday using them).
    How long does it take the average person to get into Ketsosis, I know there are a lot of variables to consider but I was wondering what people’s experience is?
    Before when I did this, the sticks were changing colour after 3 days.


  2. VLC.MD

    Focus on the process and the results will happen. Test your urine 2/week

  3. Jacob4Jesus

    How long does it take the average person to get into Ketsosis, I know there are a lot of variables to consider but I was wondering what people’s experience is?
    The average person (someone who is insulin sensitive) could be in ketosis when they get up every morning.
    I started casually and it took about 2 days for me to get the first symptoms of carb withdrawal.


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