How Metformin Cause Lactic Acidosis

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A Ci= Confidence Interval B Extended-release Metformin Was Clinically Similar To Immediate-release Metformin Based On The Pre-defined

Page 1 of 22 Metformin Hydrochloride Extended-Release Tablets 500 mg and 1000 mg Rx only DESCRIPTION Metformin hydrochloride extended-release tablets contain an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N, N- dimethylimidodicarbonimidic diamide hydrochloride) is a member of the biguanide class of oral antihyperglycemics and is not chemically or pharmacologically related to any other class of oral antihyperglycemic agents. The empirical formula of metformin hydrochloride is C4H11N5•HCl and its molecular weight is 165.63. Its structural formula is: Metformin hydrochloride is a white to off-white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. Metformin hydrochloride extended-release tablets are designed for once-a-day oral administration and deliver 500 mg or 1000 mg of metformin hydrochloride. In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: ammonio methacrylate copolymer type A, ammonio metha Continue reading >>

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Popular Questions

  1. Greg_Spletzer

    Here's the problem: I have been keto since May 2016 and now my friends are concerned with the longer term effects of this diet on me.
    Background: I'm a college student and some of my friends are Nutrition, Dietetics, and BioSystems majors. There questions get specific to the point that I can't easily respond with a formulated response to address their concerns.
    Some of the questions were:
    Doesn't your body need some carbs in order to have glucose in your bloodstream?
    a. My response: Your liver is able to produce glucose on it's own.
    b. The follow up: Well doesn't that tax your liver in the long run?
    Isn't it bad to have the higher level of acid in your blood because of the acid that's released when you break down the fat?
    Is there another short list of references, similar to Carl's http://links.2keto.com
    8 , that's more specific to specific areas of the keto diet?
    For Example, a category could be High Fat. I'd see the breakdown as
    High Fat:
    Concerned with Cholesterol --> Answer to this specific area here
    Concerned because you "must" have carbs --> Answer to this specific area here

    Edit: I know my friends are asking more of concern for me personally, they all are happy how well I've done starting keto.
    Edit2: I'm mainly looking to see if anyone has a short list/reference guide for when conversations like these come up in order to show them the science quickly and easily.

  2. AnnaLeeMI

    Gluconeogenesis is literally one of the jobs of the liver. A normal job of the liver.
    Nutritional ketosis does not cause acidosis.

    I would tell them to do their own research on Nutritional ketosis if they are so interested.

  3. janknitz

    I would think that your friend who asked the question about acidosis should go back to her biochem books and learn how minutely and exquisitely the human body regulates the pH of blood. Otherwise you'd die if you at a lemon!

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