How Glucose Is Converted Into Fatty Acids?

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Evolving Health: Why Can't We Convert Fat To Glucose?

As evident by many sugar-laden soda pop "potbellies" of North America, lipogenesis can obviously occur from drinking and eating too much sugar (1). Wouldnt it be just grand to reverse the process and be able to lose all that fat via gluconeogenesis? Unfortunately mammals do not have the ability to synthesize glucose from fats (1). The fact is that once glucose is converted to acetyl coA there is no method of getting back to glucose. The pyruvate dehydrogenase reaction that converts pyruvate to acetyl CoA is not reversible (1p252). Because lipid metabolism produces acetyl CoA via beta-oxidation, there can be no conversion to pyruvate or oxaloacetate that may have been used for gluconeogenesis (1p252). Further, the two carbons in the acetyl CoA molecule are lost upon entering the citric acid cycle (1p252). Thus, the acetyl CoA is used for energy (1p252). There are some fatty acids that have an odd number of carbon atoms that can be converted to glucose, but these are not common in the diet (1p253). Maybe they should be made more common. Do they taste good? 1. Gropper SS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism. Belmont, CA: Thomson Wadsworth, 2009. Continue reading >>

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Popular Questions

  1. zetaphine

    I'm in my 6th day of Induction and my Ketostix are not registering any changes. I drink about 112 ounces of water daily. Could I be drinking too much water and diluting the results? Thanks in advance for any light you can shed on the topic.

  2. JustJ280

    Hmmm.... well, I can say that there are people who will get into Ketosis and the strips never show anything. Not sure why -- I've never used them because I can tell when I'm there -- I feel different. But just in case, why not post an example menu so that we can see if there is anything that stands out? Sorry I couldn't be more help right off the bat!

  3. zetaphine


    Originally Posted by JustJ280
    why not post an example menu so that we can see if there is anything that stands out? JustJ280: Thanks for the quick reply! Here's today's plan:
    Breakfast:1 Atkins Bar
    2 cups coffee with heavy cream
    Snack:Red pepper slices
    Lunch:Chicken salad (canned chicken, mayo, celery, chives)
    Salad mix
    1 TBSP bacon
    2 TBSP ranch dressing
    1/4 cup mushrooms
    Dinner @ Ruby Tuesday:Sole & shrimp
    Roasted spaghetti squash
    Grilled asparagus
    I calculate 29 grams of carbs. Lemme know what you think.

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