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Glucose Ketone Index App

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The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

Go to: Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (β-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans an Continue reading >>

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Popular Questions

  1. beezala

    Hey everyone,
    I just wanted to tell people the cause of my hair loss issue, and to tell you to GO TO YOUR DOCTOR IF YOU ARE LOSING HAIR ON KETO. After 3 months I started losing hair and got a few greys, which I've never had before.
    Under everyone's advice here and on the web, I assumed it was telogen effluvium, which is common and temporary.
    After getting blood work, my doctor said I am very low in b12, which cab cause hair loss and loss of hair pigment. The solution for me: supplement daily with 1000mg b12. This is my first day supplementing.
    If left untreated, low b12 can be catastrophic. So please, do get checked out. B12 comes from animal products, so you must be wondering HOW I could possibly low on that if I eat keto.
    Apparently, it has something to do with grass fed animal products; the meat and cheese from these animals has higher levels of b12 than that of the grain fed variety. Also, it can be found in fruits and grains, which have been completely removed from my diet.
    Just some food for thought.
    EDIT: I've just read about how antibiotics can lead to b12 deficiency. I have posted before about antibiotics ruining my gut microbiome, and now I think it may have been the cause of my b12 deficiency. Apparently bad gut bacteria eats up the b12, so an overgrowth of it may be the culprit. But won't jump to conclusions until I speak with my doctor. The antibiotic I took was doxycycline for keto rash...
    UPDATE: Today is the first day I am noticing a little less hair loss than normal and it has been exactly 3 weeks since I started supplementing. There is less hair on my clothing/around me, but I am still not back to normal. Another symptom I've had is very dry/scaly/itchy scalp, which has appeared to calm down a bit the last couple of days. I'm hoping this means my body is readjusting to normal levels! Feeling optimistic.
    UPDATE 2: Confirming that after almost exactly 1 month of b12 supplementation, my hair loss is back to normal! Also, want to clarify that all of this is most likely NOT related to the Keto WOE, as my iron levels are also low and this is genetic, and apparently, they are related. Still waiting to hear from my doctor, but I may have a minor form of Thalassemia.

  2. hazeFL

    There is no B12 in fruit or grains.

  3. Addbutter

    I thought it was common knowledge since vegetarians always have to worry about not getting b12.

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