Fasting To Induce Ketosis

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Human Brain Beta-hydroxybutyrate And Lactate Increase In Fasting-induced Ketosis.

Abstract Ketones are known to constitute an important fraction of fuel for consumption by the brain, with brain ketone content generally thought to be low. However, the recent observation of 1-mmol/L levels of brain beta-hydroxybutyrate (BHB) in children on the ketogenic diet suggests otherwise. The authors report the measurement of brain BHB and lactate in the occipital lobe of healthy adults using high field (4-T) magnetic resonance spectroscopy, measured in the nonfasted state and after 2- and 3-day fasting-induced ketosis. A 9-mL voxel located in the calcarine fissure was studied, detecting the BHB and lactate upfield resonances using a 1H homonuclear editing sequence. Plasma BHB levels also were measured. The mean brain BHB concentration increased from a nonfasted level of 0.05 +/- 0.05 to 0.60 +/- 0.26 mmol/L (after second day of fasting), increasing further to 0.98 +/- 0.16 mmol/L (after the third day of fasting). The mean nonfasted brain lactate was 0.69 +/- 0.17 mmol/L, increasing to 1.47 +/- 0.22 mmol/L after the third day. The plasma and brain BHB levels correlated well (r = 0.86) with a brain-plasma slope of 0.26. These data show that brain BHB rises significantly with Continue reading >>

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Popular Questions

  1. baconrun

    Changed. Post edited.

  2. Daisy


  3. BillJay


    can I use fasting to help me become fat adapted and speed up the process at all?
    Absolutely, that's how the medical ketogenic diet has been induced for epileptics for a long time.
    The only reason it's not one of the first recommendations is that fasting is too extreme for most people and it's not required.

    Good luck!

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