Does Ketoacidosis Cause Hyperventilation Or Hypoventilation

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Hyperventilation In Severe Diabetic Ketoacidosis.

Abstract OBJECTIVE: To explore whether the carbon dioxide-bicarbonate (P(CO(2))-HCO(3)) buffering system in blood and cerebrospinal fluid (CSF) in diabetic ketoacidosis should influence the approach to ventilation in patients at risk of cerebral edema. DATA SOURCE: Medline search, manual search of references in articles found in Medline search, and use of historical literature from 1933 to 1967. DESIGN: A clinical vignette is used--a child with severe diabetic ketoacidosis who presented with profound hypocapnia and then deteriorated--as a basis for discussion of integrative metabolic and vascular physiology. STUDY SELECTION: Studies included reports in diabetic ketoacidosis where arterial and CSF acid-base data have been presented. Studies where simultaneous acid-base, ventilation, respiratory quotient, and cerebral blood flow data are available. DATA EXTRACTION AND SYNTHESIS: We revisit a hypothesis and, by reassessing data, put forward an argument based on the significance of low [HCO(3)](CSF) and rising Pa(CO(2))- hyperventilation in diabetic ketoacidosis and the limit in biology of survival; repair of severe diabetic ketoacidosis and Pa(CO(2))-and mechanical ventilation. CONCLU Continue reading >>

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Popular Questions

  1. Nabeel Ahmad

    If hyperventilation occurs, excess CO2 gets removed. This shifts the pH of the body slightly to a more alkaline ph (Since CO2 is acidic. Loss of Acid in body = Increase in pH). The change in pH can cause these effects.

  2. Meredith VIguers

    There is a delicate balance of gases in the blood, including oxygen and carbon dioxide, that regulate our system. Usually we think of oxygen as something we need to inhale and carbon dioxide as something to be expelled, but when you hyperventilate, you expel too much carbon dioxide. In the blood, carbon dioxide is important for maintaining the proper pH, as it acts as an acidifier. When too much of it is lost in a short amount of time, you go into a state of what’s called respiratory alkalosis, wherein your blood pH becomes too high or alkaline. This alkalosis causes the symptoms such as dizziness, tingling, fainting, and can even cause seizures and severe spasms if the body is unable to naturally compensate metabolically to reduce to pH of the blood to normal levels and/or the hyperventilation is stopped.

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