Dka Pathophysiology

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Diabetic Ketoacidosis: Pathophysiology, Management And Complications

Diabetic ketoacidosis (DKA) is a common and potentially life-threatening complication of diabetes mellitus, the second most common chronic childhood disease [1]. Prior to the introduction of insulin to clinical medicine by Banting and Best in 1922, DKA had a mortality rate greater than 60% [2]. As insulin was introduced into clinical practice, there was a gradual decrease in mortality associated with DKA over the subsequent 30 years. Recent epidemiological data reveal current mortality varies from 0 to 19% [3,4]. DKA continues to be the most common cause of death in patients younger than 24 years of age; it accounts for as many as 50% of deaths of young diabetic patients [5–7]. In elderly diabetics who have coexisting diseases, DKA carries a high mortality [8]. Despite many advances in the care of diabetic patients, the prevalence of DKA is not declining; it accounts for 14% of all diabetes-related hospital admissions [3, 4, 9]. The incidence of insulin-dependent diabetes mellitus continues to increase worldwide and has roughly doubled in each recent decade [10–13]. Because insulin-dependent diabetes mellitus is increasing, and preventative measures to avoid DKA in diabetic pat Continue reading >>

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Popular Questions

  1. betterfretter

    According to Arnold's encyclopedia, going into a ketogenic state causes your body to burn amino acids for energy which is bad for muscle maintenance/growth. (Not quoting directly, but that's the gist)
    Been reading some new research:
    According to the American Heart Association (AHA) Nutrition Committee, "Some popular high-protein/low-carbohydrate diets limit carbohydrates to 10 to 20 g/d, which is one fifth of the minimum 100 g/day that is necessary to prevent loss of lean muscle tissue [1]." Clearly, this is an incorrect statement since catabolism of lean body mass is reduced by ketone bodies (possibly through suppression of the activity of the branched-chain 2-oxo acid dehydrogenase), which and probably explains the preservation of lean tissue observed during very-low-carbohydrate diets. Unfortunately, the leading exercise physiology textbook also claims a "low-carbohydrate diet sets the stage for a significant loss of lean tissue as the body recruits amino acids from muscle to maintain blood glucose via gluconeogenesis [2]." Thus, it is certainly time to set the record straight.
    Source: http://www.jissn.com/content/1/2/7
    What are your thoughts on this? Ketosis is OK for fat loss while maintaining/growing?

  2. myhipsi

    According to Arnold's encyclopedia, going into a ketogenic state causes your body to burn amino acids for energy which is bad for muscle maintenance/growth.
    This is correct. Carbohydrates are protein sparing and glucose (the end product of carbohydrate) is REQUIRED for explosive muscular contraction/tension. So, if you fail to eat adequate amounts of carbohydrate to replenish glycogen stores, it will have a definite impact on strength. When glucose is severely lacking in the diet, the body will ramp up gluconeogenesis which is when the body uses fats and AMINO ACIDS to produce the required glucose your body uses, so you end up converting much of the protein you eat (and possibly muscle tissue itself) into glucose for fuel.
    In short: Ketosis (severe carbohydrate restriction) can be used as a dietary tool for people that are severely overweight/obese and SEDENTARY. For those that endeavor into weight training/body building or any other high performance based activity/sport, carbohydrates are required maximum performance.

  3. Bojangles010

    Yep. Did a research paper on this and came to the same conclusion. Keto is fantastic for weight loss, but not for any type of athletes or those looking to gain strength/mass. I really like your quick summary.

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