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Causes Of Metabolic Acidosis

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Approach To The Adult With Metabolic Acidosis

INTRODUCTION On a typical Western diet, approximately 15,000 mmol of carbon dioxide (which can generate carbonic acid as it combines with water) and 50 to 100 mEq of nonvolatile acid (mostly sulfuric acid derived from the metabolism of sulfur-containing amino acids) are produced each day. Acid-base balance is maintained by pulmonary and renal excretion of carbon dioxide and nonvolatile acid, respectively. Renal excretion of acid involves the combination of hydrogen ions with urinary titratable acids, particularly phosphate (HPO42- + H+ —> H2PO4-), and ammonia to form ammonium (NH3 + H+ —> NH4+) [1]. The latter is the primary adaptive response since ammonia production from the metabolism of glutamine can be appropriately increased in response to an acid load [2]. Acid-base balance is usually assessed in terms of the bicarbonate-carbon dioxide buffer system: Dissolved CO2 + H2O <—> H2CO3 <—> HCO3- + H+ The ratio between these reactants can be expressed by the Henderson-Hasselbalch equation. By convention, the pKa of 6.10 is used when the dominator is the concentration of dissolved CO2, and this is proportional to the pCO2 (the actual concentration of the acid H2CO3 is very lo Continue reading >>

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Popular Questions

  1. TexasEric

    How long does it take to get back into ketosis after a cheat day/meal?

    My family went to my In-laws house this Sunday. I LOVE wife's family. I should not have gone, they ALWAYS feed me good. I always binge over there. This was no different, I was weak. Luckily this only happens once every few months.
    How long does it take to get back into ketosis after cheating. I just started lifting again this week so that should help. I also intend to keep running at least 2x a week. My new weekly diet is about 20-30 carbs a day. Started doing hard cheese and fatty meats for dinner to get my fat up for the day up and keep my carbs down.
    I fully expect some flaming, but knowledge would be more helpful.

  2. CoffeeStout

    I think it will be slightly different for each person. After a carb load in the past I would return to ketosis usually within 12 hours or sooner.

  3. boyselier

    [QUOTE=TexasEric;1490641601]My family went to my In
    For me personally it can take 2 or 3 days, If I do a tabatta work out (20 sec. on and 10 sec. rest 4 min total time) I been able to cut it down to 24 hours. You basically have to get rid of all the stored glycogen in your body in order to start metabolizing fat for ketones. People usually use a HIIT work out since that taps into your glycogen stores for energy, steady state cardio wont cut it.
    Try the tabatta work out on sprints a treadmill or a elliptical, but remember its 20 seconds of INTENSE work don't cut yourself short and catch your breath for 10 seconds and repeat you should only be able to do 4 min of this. If you can go longer you cheated and did not do it right.
    I sometimes will throw fasting into the mix as well since your guaranteed no carbs and a low insulin levels. But no everyone can mentally do that.

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