Alcoholic Ketoacidosis Pathophysiology

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Alcoholic Ketoacidosis

Go to: CHARACTERISATION In 1940, Dillon et al1 described a series of nine patients who had episodes of severe ketoacidosis in the absence of diabetes mellitus, all of whom had evidence of prolonged excessive alcohol consumption. It was not until 1970 that Jenkins et al2 described a further three non‐diabetic patients with a history of chronic heavy alcohol misuse and recurrent episodes of ketoacidosis. This group also proposed a possible underlying mechanism for this metabolic disturbance, naming it alcoholic ketoacidosis. Further case series by Levy et al, Cooperman et al, and Fulop et al were subsequently reported, with remarkably consistent features.3,4,5 All patients presented with a history of prolonged heavy alcohol misuse, preceding a bout of particularly excessive intake, which had been terminated several days earlier by nausea, severe vomiting, and abdominal pain. Clinical signs included tachypnoea, tachycardia, and hypotension. In 1974, Cooperman's series of seven ketoacidotic alcoholic patients all displayed diffuse epigastric tenderness on palpation.4 In contrast to patients with diabetic ketoacidosis, the patients were usually alert and lucid despite the severity of Continue reading >>

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Popular Questions

  1. sanan

    can't sleep..please help

    I'm on my 4.day of my keto bulk and my problem is that I can't sleep. (entered ketosis on day3)
    I have lots of energy and my body just won't settle down when it comes to sleeping. I wake up during midnight to take a pee, then can't sleep after that.
    I workout 2 times a day, 5 days/week. not to mention being on my feet at least 6 hours a day. I just don't feel a need to sleep.
    extra information incase you need them: I'm currently on a keto bulk (25%protein, 7%carb, 68%fat) with 1200-1300cals above maintenance and 1,8g protein/ lb LMB.
    please help

  2. Fitnessmade

    Are you taking any suplements ?
    Any caffeine ?
    Any kola nut, ginseng, guarana ?
    List them here !

  3. Atropa

    melatonin, get some

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