Which Insulin Can Be Used As A Basal Insulin?

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Basal Basics

Pumper’s Voice When it comes to managing diabetes, basal insulin gets very little respect. Most people can’t spell it correctly (basil? basul?), and even fewer know what it’s even used for. And that’s a shame, because basal insulin represents the FOUNDATION upon which insulin therapy is built. Basal insulin’s job is to offset the liver’s secretion of glucose into the bloodstream. Everyone’s liver does it, mainly to supply the brain and nervous system with a steady supply of energy, and mainly in response to the many hormones that are in circulation. Because the liver is secreting sugar into the bloodstream continuously, a lack of insulin would result in a sharp rise in blood sugar levels. It would also cau Continue reading >>

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Popular Questions

  1. Qinghao Zhang

    Recently I've prepared to add insulin solution to the cell culture, but I find insulin is difficult to resolve. Below is my protocol to resolve insulin, could you give me some advise? My protocol stock solution of insulin was prepared in 0.5M Tris-HCl, pH7.0, by suspending 50mg of insulin in 2.5 mL of buffer and adjusting pH to about 3 with 1M HCl to dissolve the insulin. Then the solution was back titrated to pH 7.0 with 1M NaOH (note: the solution becomes cloudy and precipitation appears again, why ?)

  2. marie-catherine Giarratana

    Insulin has to be diluted at low pH for a better solubility.
    We dissolve Insulin at 1 or 2mg/mL in HCl 5mM (ie pH 2.3) but the final concentration in the culture medium is around 10µg/mL. Consequently, after a dilution factor of 100 or 200, no problem is observed for cells.

  3. Ru-Jeng Teng

    Do you mean "dissolve"? Insulin is a very water soluble protein and I can not understand why you need to adjust pH to 3.0 then titrate it back to pH 7.0. The low pH may already denature your insulin. I have never seen anybody in our lab using pH 3.0 to dissolve insulin before putting into the culture medium.

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