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Where Are Insulin Receptors Located

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Histologic Distribution Of Insulin And Glucagon Receptors

M. Watanabe, H. Hayasaki, T. Tamayama and M. Shimada Department of Anatomy, Osaka Medical College, Takatsuki, Osaka, Japan Insulin and glucagon are the hormonal polypeptides secreted by the B and A cells of the endocrine pancreas, respectively. Their major physiologic effects are regulation of carbohydrate metabolism, but they have opposite effects. Insulin and glucagon have various physiologic roles, in addition to the regulation of carbohydrate metabolism. The physiologic effects of insulin and glucagon on the cell are initiated by the binding of each hormone to receptors on the target cells. Morphologic studies may be useful for relating biochemical, physiologic, and pharmacologic information on the receptors to an anatomic background. Receptor radioautography techniques using radioligands to label specific insulin and glucagon receptors have been successfully applied to many tissues and organs. In this review, current knowledge of the histologic distribution of insulin and glucagon receptors is presented with a brief description of receptor radioautography techniques. Key words: radioautography, insulin, glucagon, receptor, distribution Introduction Insulin is a hormone secrete Continue reading >>

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Popular Questions

  1. Liang-Hai Sie

    Insulin

    Cells (biology)

    Cell Biology

    Biochemistry

    Neuroscience

    Biology



    Do all human cells have insuline receptors?




    1 Answer







    Most cells have insulin receptors, from The Insulin Receptor and Its Signal Transduction Networ


    Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting through a receptor located in the membrane of target cells - major ones being liver (where it promotes glucose storage into glycogen and decreases glucose output), as well as skeletal muscle and fat (where it stimulates glucose transport through translocation of GLUT4), but also b cells, brain cells and in fact most cells, where it has pleiotropic effects.

    304 Views · 4 Upvotes · Answer requested by Filipe Castro








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    Related Questions



    Do all human cells have the same surface receptors?


    What is cell receptors?


    What cells secrete insulin?


    Are there insulin receptors in the brain?


    Can somatic cells make insulin?


    What are insulin receptor knockout mice?


    What's the difference between human insulin vs human soluble insulin?


    How is human insulin produced?


    Is increased insulin resistance specific to translocation of GLUT4 receptors to the cell membrane? Or does insulin resistance also downregulat...


    What is the target cell of insulin?
    Ask New Question

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