What Is The Best Form Of Insulin For Diabetes? Synthetic Or Human Insulin And Why?
We want to mimic the body's own insulin by injecting insulin of different kinds multiple times a day. First we need a super-stable super-long acting insulin which will be continuously effective over 24+ hours, without troughs and peaks, only the newest synthetic analogues do this, the most stable being Novo Nordisk's new Insulin degludec (Tresiba®), before that we had Aventis' quite acceptable Insulin glargine (Lantus®) and NovoNordisk's Insulin detemir (Levemir®). As you can see the glucose needed to be infused to keep the blood glucose level steady over time after Insulin Degludec is stable, but after 8-10 hours rises, peaking at 14-16 hours and going down a lot at 18-20 hours after Insuline Glargine injection: So Insulin Degludec seems more stable than Insulin Glargine. We also want the effect of an insulin to be consistent (the same after each injection on different days): You can see why the old NPH insulin has had its day, peaking at 8 hours and losing potency after 16 hours: If the pancreas is still making enough insulin to regulate the blood sugar after meals, we only need one usually injection of a super long acting insulin analogue before bedtime to keep the blood suga Continue reading >>