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What Is The Duration Of Regular Insulin?

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Confusion Regarding Duration Of Insulin Action

Go to: Abstract People with diabetes on insulin pumps often use a bolus calculator (BC) to obtain insulin dose recommendations. After the first bolus of the day, residual insulin activity, called bolus insulin on board (BOB), must be correctly accounted for to reduce the size of subsequent boluses and minimize the insulin stacking that would otherwise occur. Critical to achieving this calculation is having an appropriate duration of insulin action (DIA) setting in the BC. Unfortunately, the widespread use of inappropriately short DIAs may be causing unrecognized “stacking” of insulin that leads to unexplained hypoglycemic events. Currently, there is no widely accepted definition or value of the DIA for use in a BC. Various shortcomings regarding the selection of an appropriate DIA setting have led to considerable confusion among clinicians and insulin pump users about this important concept. Traditional pharmacological studies used to determine the pharmacodynamic (PD) properties of rapid-acting insulins create a misleading impression that insulin action times (IATs) in daily life vary from 3 to 5 hours and cause IATs to appear more variable than they actually are. These IAT ti Continue reading >>

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  1. Lloyd

    Types of Insulin

    Insulin is divided into types, based on how long it is active in your body. This helps match insulin with a specific need.
    Rapid Acting
    Intended to be taken at the same time as meals
    Humalog or lispro
    Onset: 15-30 minutes
    Peak 30-90 minutes
    Duration 3-5 hrs
    Should be taken 15 minutes before or immediately after a meal

    Humalog Prescribing Info
    Novalog, AKA Novorapid, aspart
    Onset: 5-10 minutes
    Peak: 40-50 minutes
    Duration: 3-5 hrs
    Should be given 5-10 minutes before the start of a meal

    Novolog Prescribing Info
    Apidra or glulisine

    Onset: 20-30 minutes
    Peak: 60-90 minutes
    Duration: 1-2.5 hrs
    Take 15 minutes before to 20 minutes after starting a meal

    Apidra Prescribing Info
    Short-acting
    Intended for meals eaten within 30 - 60 minutes
    Humulin
    Onset: 30-60 minutes
    Peak 2-5 hrs

    Duration: 5-8 hrs
    Novolin

    Onset: 30-60 minutes
    Peak: 2-5 hrs

    Duration 5-8 hrs
    Intermediate-acting
    Covers your needs for half a day, or overnight
    NPH
    Onset: 2-4 hours
    Peak: 4-12 hours

    Duration: 12-18 hours
    U500

    U-500 insulin is regular insulin in 500 units/mL concentration (as opposed to the standard 100 units/mL). Useful for extreme insulin resistance (with typical daily requirements over 200 units/day).
    Lente

    Onset: 1.5 hrs
    Peak: 4-8 hrs

    Duration: 24 hours
    Long-acting
    Intended to last a day
    Ultralente (no longer manufactured)
    starts working in 4-6 hours

    active well beyond 32 hours.
    Lantus
    Onset 3-4 hours
    Peak 6-8 hours
    Duration 18-24 hrs

    information for Lantus®.
    Levemir or Detemir

    Used once or twice a day

    Levemir® Prescribing Information
    Insulin Mixtures
    Starts working in 30 minutes and is active 16 to 24 hours.
    Usually taken twice a day at mealtimes

    There are several variations with different proportions of the mixed insulins.


    Humulin 70/30
    Novolin 70/30
    Novolog 70/30
    Humulin 50/50

    Humalog mix 75/25
    This is a work in progress. Contributions welcomed, please send me a PM
    Thanks to saraknic for the cool formatting!
    Thanks to skessdtrek for the U-500 info.
    -Lloyd

  2. drewgolden

    Another very nice contribution from Lloyd!
    Thanks!
    drew

  3. RainLover

    Would you kindly advise from where did you obtained the information that the duration time for Apidra is 1 to 2.5 hours.
    Thanks

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