What Is Insulin Sensitivity

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Micrornas 103 And 107 Regulate Insulin Sensitivity

Defects in insulin signalling are among the most common and earliest defects that predispose an individual to the development of type 2 diabetes1,2,3. MicroRNAs have been identified as a new class of regulatory molecules that influence many biological functions, including metabolism4,5. However, the direct regulation of insulin sensitivity by microRNAs in vivo has not been demonstrated. Here we show that the expression of microRNAs 103 and 107 (miR-103/107) is upregulated in obese mice. Silencing of miR-103/107 leads to improved glucose homeostasis and insulin sensitivity. In contrast, gain of miR-103/107 function in either liver or fat is sufficient to induce impaired glucose homeostasis. We identify caveolin-1, a critical regulator of the insulin receptor, as a direct target gene of miR-103/107. We demonstrate that caveolin-1 is upregulated upon miR-103/107 inactivation in adipocytes and that this is concomitant with stabilization of the insulin receptor, enhanced insulin signalling, decreased adipocyte size and enhanced insulin-stimulated glucose uptake. These findings demonstrate the central importance of miR-103/107 to insulin sensitivity and identify a new target for the trea Continue reading >>

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  1. trikesterkyote

    Sperm-Producing Cells Coaxed to Produce Insulin

    From Yahoo news Dec. 18, 2010.

  2. furball64801

    It seems there is no end to what they will try and use.

  3. deanusa

    hmmm well for gosh sakes.
    ""And the other limitation is that this is only for men, not for women."
    that should go over real big.
    "This study is a positive step, but you still have a risk of teratomas, and the autoimmunity could destroy the new insulin-producing cells," said one expert, Dr. Camillo Ricordi"
    "But, perhaps a bigger concern in replacing beta cells, said Riccordi, is the potential of causing dangerously low blood sugar levels. Both beta and alpha cells are destroyed in people with type 1 diabetes, and alpha cells produce glucagon, a hormone that increases blood sugar levels in the body when they drop too low. So, if researchers only replace insulin-producing beta cells, and not alpha cells, there is a potential of causing low blood sugar levels, which can also be deadly."
    pretty much sounds like all around fun to me.
    i dont really see being able to get away with something that only works on men.i mean really whats the point of even thinking about this.since it is a equal opportunity condition should nt time and money be spent on equal opportunity cures?would this even be considered if they said it only works on male caucasians?

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