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Should Insulin Be Kept Cold

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Must Insulin Be Stored In The Refrigerator?

I have a newly diagnosed diabetic dog on NPH insulin, whose owner has not been refrigerating the insulin (Novolin N). I instructed him to store the open insulin vial in the refrigerator. However, the pharmacy where he purchased the insulin put a sticker on the vial that says it can be left at room temperature. The owner also claims he looked it up online and says it doesn't have to be refrigerated. I have always been taught that insulin must remain in the refrigerator or it loses it's "potency." I did look up the FDA Patient Package Insert online, which says the following: All Unopened Novolin N: Keep all unopened Novolin N in the refrigerator between 36° to 46°F (2° to 8°C). Do not freeze. Do not use Novolin N if it has been frozen. If refrigeration is not possible, the unopened vial may be kept at room temperature for up to 6 weeks (42 days), as long as it is kept at or below 77°F (25°C). Keep unopened Novolin N in the carton to protect from light. Opened Novolin N Vials: Keep at room temperature below 77°F (25°C) for up to 6 weeks (42 days). Keep vials away from direct heat or light. Throw away an opened vial after 6 weeks (42 days) of use, even if there is insulin left Continue reading >>

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  1. cz_dave

    I am in Italy now and it gets very hot during the day. The temperature in my room easily reaches 30 degrees C and sometimes exceeds it. I put the insulin I use in a fridge I have in my room. I am not sure this is a good practice: putting the insulin I have stored in rooom temperature back into a fridge. I also have a frio with me but have not used it yet.
    I suppose I should use the frio. But has anyone seen any detrimental effects to NovoRapid or Levemir if you put it back to fridge after having been stored at room room tempreature?
    Thanks.

  2. noblehead

    Once the insulin has been out of the fridge and at room temperature it should be used up within 4 weeks, that is the manufacturers advice and says so in the patient leaflet.

  3. cz_dave

    noblehead said: ↑
    Once the insulin has been out of the fridge and at room temperature it should be used up within 4 weeks, that is the manufacturers advice and says so in the patient leaflet. Ok. So as long as I do not exceed the 4 weeks, I can keep storing it at room temperature and in the fridge interchangeably without any problems.

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