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Should Insulin Be Capitalized

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Pronunciation flashcards for the print, e-book, and pharmacology audiobook Memorizing Pharmacology: A Relaxed Approach. More difficult medication names will have two pronunciation videos, a flashcard short version and an extended version breaking the pronunciation down syllable by syllable.

Future Prospect Of Insulin Inhalation For Diabetic Patients: The Case Of Afrezza Versus Exubera

Abstract The current review was designed to compare between the insulin inhalation systems Exubera and Afrezza and to investigate the reasons why Exubera was unsuccessful, when Afrezza maker is expecting their product to be felicitous. In January 2006, Pfizer secured FDA and EC approval for the first of its kind, regular insulin through Exubera inhaler device for the management of type 1 and 2 diabetes mellitus (DM) in adults. The product was no longer available to the market after less than two years from its approval triggering a setback for competitive new inhalable insulins that were already in various clinical development phases. In contrary, Mannkind Corporation started developing its ultra-rapid-acting insulin Afrezza in a bold bid, probably by managing the issues in which Exubera were not successful. Afrezza has been marketed since February, 2015 by Sanofi after getting FDA approval in June 2014. The results from this systematic review indicate the effectiveness of insulin inhalation products, particularly for patients initiating insulin therapy. Pharmaceutical companies should capitalize on the information available from insulin inhalation to produce competitive products t Continue reading >>

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  1. Stump86

    Another quick question about insulin!
    Say you know you have 4U insulin on board after some meal and you're wanting to take a correction and factor in that IOB. Is that 4U IOB the same as if you had just injected 4U of insulin, or is it somehow diminished having come from an earlier injection? Thanks!

  2. hypercarmona

    It varys from person to person, but I've always assumed that around 15-25% is used per hour after injection. For example, if it's only been 30 minutes since my injection, I'd lop off only 10%. This would leave me with 3.6 units on board for a 4 unit bolus. If this amount is greater than the amount of correction I'd need to take, I wouldn't necessarily need to take a correction.

  3. Richard157

    Carmona seems to deal with this the same way I do. If you took 4U before a meal and your ISF is 4 (insulin lasts 4 hours before giving out) then there is a 3U IOB 1 hr after the meal, 2U at 2hr, 1U at 3hr and 0U at 4hr. This assumes your fast acting does last 4 hr. I use Humalog and I think you use Novolog so it may not last as long??? This is the way my pump is programmed to work.
    Richard

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Efficacy of Humalog Mix75/25 Humalog Mix75/25 provided improved glucose control Two studies in adult patients with type 2 diabetes When added to metformin, Humalog Mix75/25 improved A1C1 Two open-label, randomized, crossover trials compared the glycemic response of Humalog Mix75/25 BID + metformin with that of glargine QD + metformin1,2 Humalog Mix75/25 improved fasting blood glucose (FBG) and postprandial glucose (PPG) control3 A randomized, double-blind study with 3-way crossover compared Human Insulin 70/30, Humalog Mix75/25, and Humalog® Mix50/50™ after a standardized breakfast meal3 PAIR-IN: Design and methods1 Humalog Mix75/25 BID plus metformin versus glargine QD plus metformin Open-label, randomized, crossover trial, 16 weeks on each treatment 105 insulin-naive patients with type 2 diabetes Mean age 55 years All randomized patients included in safety analysis 67 patients included in efficacy analysis (29 patients excluded because they may have received expired study drug) Baseline A1C: 8.7% Primary endpoint Note: PAIR-IN average (standard deviation) daily dose of insulin was 0.62 (0.37) U/kg for Humalog Mix75/25 vs 0.57 (0.37) U/kg for glargine (P<.001). PAIR-PI: Design Continue reading >>

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Popular Questions

  1. Stump86

    Another quick question about insulin!
    Say you know you have 4U insulin on board after some meal and you're wanting to take a correction and factor in that IOB. Is that 4U IOB the same as if you had just injected 4U of insulin, or is it somehow diminished having come from an earlier injection? Thanks!

  2. hypercarmona

    It varys from person to person, but I've always assumed that around 15-25% is used per hour after injection. For example, if it's only been 30 minutes since my injection, I'd lop off only 10%. This would leave me with 3.6 units on board for a 4 unit bolus. If this amount is greater than the amount of correction I'd need to take, I wouldn't necessarily need to take a correction.

  3. Richard157

    Carmona seems to deal with this the same way I do. If you took 4U before a meal and your ISF is 4 (insulin lasts 4 hours before giving out) then there is a 3U IOB 1 hr after the meal, 2U at 2hr, 1U at 3hr and 0U at 4hr. This assumes your fast acting does last 4 hr. I use Humalog and I think you use Novolog so it may not last as long??? This is the way my pump is programmed to work.
    Richard

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Enhanced Glycemic Control With Combination Therapy For Type 2 Diabetes In Primary Care

Go to: Globally, the World Health Organization (WHO) reports that as many as 220 million individuals have diabetes.1 The Framingham Offspring Study database indicates that the incidence of type 2 diabetes mellitus (DM2) has doubled in the US from the 1970s through the 1990s.2 In the US, it was estimated in 2010 that nearly 26 million individuals had diabetes, of which 7.0 million (27%) were undiagnosed.3 Furthermore, the prevalence of diabetes (driven largely by DM2) is projected to reach 12.0% by 2050, affecting more than 48 million individuals.4 Disconcertingly, almost half of deaths in this population occur before the age of 70 years, and the WHO projects that the number of diabetes deaths will double between 2005 and 2030. Clinicians also increasingly recognize the additional burden of DM2 in children and adolescents.5 Most patients with DM2 are appropriately managed within the primary care sector, with the occasional need for consultation by diabetologists. Since DM2 is associated with increased mortality, increased risk of macrovascular disease (ie, stroke and myocardial infarction), and increased microvascular disease (ie, retinopathy, nephropathy, and neuropathy), there are Continue reading >>

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  1. rudreshs1

    Hi everyone there in this forum. I am very happy about this forum. We can interact and solve so many drug-related issues like formatting, sound-alikes, etc.
    I am very confused about the initial capitalization of the drug "Regular Insulin." Is it Regular Insulin? OR regular insulin? OR Regular insulin.
    Also, if doc dictates Toprol Extended Release Tablets, do we need to transcribe Toprol extended release tablets or Toprol Extended Release Tablets. Product website - www.toprol-xl.com show this drug with initial caps.
    tx

  2. MarthaRuthyLu

    Hi, I'm new, too, as of this week.
    Re "Regular Insulin" whether to cap both words. In my QUICK LOOK program, found all antidiabetic agents under one heading: Insulin Preparations. Regular Insulin was not listed, but Regular Iletin® II was (as distinguished from NPH Iletin® II]). But context is everything. If the doc really said "regular insulin," I wouldn't cap either word starting a sentence, duh. Or shehe could've named the specific drug but it came on tape as "insulin" instead of "Iletin." If still doubting, and your person dd(shehe)is amenable to questions, I would ask.
    Of the times I didn't ask when in doubt, 95% of the time I wish I had. My word to the wise with hopes it will suffice.
    As to Toprol, the exact name is Toprol-XL® [US/Can]. But the doc would probably just cap the Toprol; i.e. Toprol extended-release tablets. Otherwise, he/she would have dictated [i]"Toprol-XL tablets."[[i]
    By now you've probably received ten replies, 'specially if you're on the east coast. So, please pardon the redundance.
    Til next time, I am
    still
    "aging Ruth"

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