Short Acting Insulin

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Fda Says 'yes' To Short-acting Insulin Admelog

The FDA granted full approval for the first "follow-on" version of short-acting insulin lispro, to be sold as Admelog and indicated for improving glycemic control, the agency announced Monday. The approval covers use in adults with type 2 diabetes, as well as in adults and children at least 3 years old with type 1 diabetes. Typically administered prior to meals, the insulin can be given via injection, through an insulin pump, or by intravenous infusion. Admelog, developed by Sanofi, is a follow-on to Eli Lilly's insulin lispro sold as Humalog and was therefore reviewed under the abbreviated 505(b)(2) pathway, which is separate from the FDA's so-called biosimilar pathway although functionally there is little to distinguish them. Sanofi's insulin lispro had been tentatively approved in September with final approval withheld while patent issues were resolved. Admelog's approval was also based on two phase III clinical trials involving around 1,000 patients. During the clinical trials, the most commonly reported adverse events included hypoglycemia, itching, and rash. Continue reading >>

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Popular Questions

  1. Cat Ma

    I am trying to figure out how much time prior to giving insulin I should feed my cat.
    The vet said 10 to 15 minutes; others say 30 minutes to an hour.
    What works for your cat?

  2. Wendy&Neko

    Most people here test, feed, and shoot insulin all within 15 minutes. Several will give insulin while the cat has his head in the bowl.

  3. Elizabeth and Bertie

    When giving insulin, it's important to know that the cat is actually eating normally and will have food 'on board' for when the insulin starts working. So, you can feed prior to the shot, or (if you're confident your cat is eating normally) you can give the shot while the cat is eating.
    What you don't want to happen is that you give the shot and then find out that the kitty doesn't want to eat.
    There are instances in which folks might wait a while after feeding before giving insulin. For example:
    Some folks whose kitties have sensitive GI issues may wait a while after feeding to ensure their kitty isn't going to regurgitate the food.
    And I've known some folks using faster acting insulins to feed first and then wait a short while to ensure that the food is getting into the system before they give the insulin shot.
    In a nutshell though, the sequence is:
    1. Test - to check the blood glucose is high enough to warrant that insulin dose.
    2. Feed - to ensure the kitty will have food on board when the insulin kicks in.
    3. Shoot - give insulin.

  4. -> Continue reading
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