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Short Acting Insulin

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Short-acting Insulin

Replaced by insulin analogues as the quickest acting insulins. Often known as soluble or ‘regular’ or 'neutral' insulin. Some features of short-acting or neutral insulins include: peak 2-6 hours after subcutaneous injection tendency to form hexamers in the insulin vials - these dissociate slowly leading to reduction in absorption rate onset of action 30–60 mins peak 2–4 hours in some individuals can have an effect 8-12 hours after administration of injection injected 20-30 minutes before a meal may result in postprandial and nocturnal hypoglycaemia because of long-lasting effects in some patients short-acting insulins remain the optimum quick-acting insulin examples Human Actrapid®, Humulin S®, Insuman® Rapid? (also porcine and bovine equivalents of these) note that some of these insulins are also licensed for use in continuous subcutaneous insulin infusion i.e. insulin pumps (1) Examples include human actrapid. Reference: MeRec Bulletin 2007;17(4). Prescriber 2001;12 (14): 43-50 Continue reading >>

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Popular Questions

  1. strack350

    Hello all, just recived a letter from my insurance company stating they will no longer be paying for Eli Lilly branded insulin producs"with the exeption of U500, Lantus, and Apidra". Anyways, they cover all NovoNordisk products. I currently use Levemir, so I'm covered there buy I've never used Novolog. In looking at the two insulins, they "should" work similar, if not the same for my bolusing needs. Has anyone here made the switch, or should I maybe look into Apidra. I'm just looking for some opinions because they stop covering my Humalog next month and I want to get a script for the optimal insulin for my needs.

  2. mmmtat

    I have no idea but I'm curious about this as well. I was put on novolog but was told at the time that humalog was the same. Maybe it just depends on which drug rep has stopped by the doctors office lately?

  3. Gigem99

    There are 3 major manufacturers of insulin: Eli Lilly, NovoNordisk and Sanofi. All 3 make rapid-acting insulin analogues: Lilly makes Humalog, NovoNordisk makes Novolog and Sanofi makes Apidra.
    NovoNordisk and Sanofi make long-lasting (24-hour) analogues: NovoNorisk makes Levemir, while Sanofi makes Lantus. Lilly makes a mixture (70/30 or 50/50) of Humalog mixed with Humalog protamine (a longer acting insulin).
    I've used Humalog, Novolog and Apidra. For me, Humalog and Novolog are functionally equivalent. Apidra seems to behave a little differently. Some folks who inject say Apidra seems to act a little quicker and last a little shorter than Humalog or Novolog. I don't know about that, because I only used Apidra in my pump. I do know that I seemed to use a little more Apidra than Humalog or Novolog. I prefer Humalog or Novolog - again, I've seen no difference between the two.
    Before I started pumping, I briefly used Lantus, but I've never used Levemir - my understanding is that they are very similar. I used NPH/R for over 20 years, and all the analogues are a bunch better than that. I'll swear, NPH was the devils insulin for me.

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