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Medtronic Minimed 670g Trial Results: 44% Reduction In Hypoglycemia, 0.5% A1c Improvement

Highlights from the first study of a commercial automated insulin delivery device. Plus, Medtronic’s latest software updates! At the recent ADA Scientific Sessions, Medtronic presented data from its pivotal trial of the MiniMed 670G/Enlite 3 hybrid closed loop system, designed to provide evidence for regulatory approval. Compared to a two-week, “open-loop” phase (pump + CGM without automation), adolescents and adults spending three months on the hybrid closed loop system saw: A 0.5% reduction in A1c, bringing patients from a low initial A1c of 7.4% to 6.9%; A 44% reduction in time spent with low blood glucose (under 70 mg/dl); A 40% decline in time spent in dangerous hypoglycemia (under 50 mg/dl); An 11% decline in time spent over 180 mg/dl and an 8% improvement in time-in-range (71-180 mg/dl). This dual reduction in A1c and hypoglycemia demonstrates the power of automating insulin delivery – shaving off lows AND highs, particularly overnight. Take note of the images below, which show the combined daily glucose profiles in adults (B) and adolescents (C) for the open loop run-in (gray) and hybrid closed-loop with the MiniMed 670G (pink). The 670G tightened the range of gluco Continue reading >>

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Popular Questions

  1. kgm0612

    According to my pump manual, Insulin Sensitivity is the amount your blood sugar level is reduced by one unit of insulin and that this value amount is used to calculate a suggested bolus insulin dose to correct your BS when it's above the target range.
    I started on the MM-515 in mid-December with an insulin sensitivity setting of 133, set by my endo & pump trainer. After chatting with several pump users and asking what their level was set at, over the last several months I have lowered my level down to 45.
    I guess what I'm trying to get to is this..........when I correct because my BS is above my target range, then my BS should be dropping 45 points for every unit I give myself to correct? This certainly wasn't happening when it was set at 133, or 90, or 75.
    If someone could help me out and explain this all to me, I'd appreciate it!
    Karen

  2. Funnygrl

    If your ISF really is 45, then yes, bs should drop 45 for every unit. I'm kinda surprised they didn't work with you to figure this out before starting pump, at least roughly, and explain it better.
    So if your ISF was 45 and your target bs was 100, to correct a 190 you would take two units because:
    (current-target)/ISF= correction
    so:
    190-100=90/45=2

  3. spike

    kgm0612 said:

    According to my pump manual, Insulin Sensitivity is the amount your blood sugar level is reduced by one unit of insulin and that this value amount is used to calculate a suggested bolus insulin dose to correct your BS when it's above the target range.
    I started on the MM-515 in mid-December with an insulin sensitivity setting of 133, set by my endo & pump trainer. After chatting with several pump users and asking what their level was set at, over the last several months I have lowered my level down to 45.
    I guess what I'm trying to get to is this..........when I correct because my BS is above my target range, then my BS should be dropping 45 points for every unit I give myself to correct? This certainly wasn't happening when it was set at 133, or 90, or 75.
    If someone could help me out and explain this all to me, I'd appreciate it!
    Karen
    Wow! 133??? My number is between 22 and 38. 22 in the pre dawn hours, and closer to 38 during the day. Don't forget you have to wait the full 3.5-5 hours for your bg to drop the full amount. don't expect it to drop by your ISF within a hour or two...

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