Long Acting And Short Acting Insulin

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Insulin – Pharmacology, Therapeutic Regimens And Principles Of Intensive Insulin Therapy

Go to: Since the introduction of insulin analogs in 1996, insulin therapy options for type 1 and type 2 diabetics have expanded. Insulin therapies are now able to more closely mimic physiologic insulin secretion and thus achieve better glycemic control in patients with diabetes. This chapter reviews the pharmacology of available insulins, types of insulin regimens and principles of dosage selection and adjustment, and provides an overview of insulin pump therapy. For complete coverage of this and related aspects of Endocrinology, please visit our FREE web-book, www.endotext.org. Go to: PHARMACOLOGY In 1922, Canadian researchers were the first to demonstrate a physiologic response to injected animal insulin in a patient with type 1 diabetes. In 1955, insulin was the first protein to be fully sequenced. The insulin molecule consists of 51 amino acids arranged in two chains, an A chain (21 amino acids) and B chain (30 amino acids) that are linked by two disulfide bonds (1) (Figure 1). Proinsulin is the insulin precursor that is transported to the Golgi apparatus of the beta cell where it is processed and packaged into granules. Proinsulin, a single-chain 86 amino acid peptide, is clea Continue reading >>

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Popular Questions

  1. Stacey H

    I am going to be starting insulin either a Thursday or Friday. I'm not sure which insulin I will take but my doctor said I will take a rapid acting insulin and a long lasting insulin. Is there anything I should know before I use it? For those on insulin is there anything you know now that you wished you knew when you started insulin? I have heard you gain weight with insulin. How much weight should I expect to gain?

  2. mo1905

    Hi Stacey, your nurse will go over everything with you before you get your insulin. Make sure you test regularly as it may take a few days to get your dose sorted out. As for weight gain, eat sensibly and exercise and shouldn't be a problem. Enquire about a DAFNE course but there will be a waiting list. Good luck, Mo
    Sent from the Diabetes Forum App

  3. monkeynuts

    I would certainly recommend the DAFNE course. I had diabetes for 26 years before going on one and learnt a lot.

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