Effects Of Metformin On Insulin Resistance And Metabolic Disorders Intumor-bearing Rats With Advanced Cachexia.
1. Can J Physiol Pharmacol. 2018 Jan 5:1-8. doi: 10.1139/cjpp-2017-0171. [Epub aheadof print] Effects of metformin on insulin resistance and metabolic disorders intumor-bearing rats with advanced cachexia. de Fatima Silva F(1), Ortiz-Silva M(1), Galia WBS(1), Cassolla P(1), da SilvaFG(2), Graciano MFR(1), Carpinelli AR(2), de Souza HM(1). (1)a Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil. (2)b Department of Physiology and Biophysics, University of So Paulo, 05508-900, So Paulo, SP, Brazil. Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistanceand metabolic disorders associated with cancer cachexia is not established. Weinvestigated the MET effects, isolated or associated with INS, on INS resistance and metabolic changes induced by Walker-256 tumor in rats with advanced cachexia.MET (500 mgkg-1, oral) and MET + INS (1.0 IUkg-1, s.c.) were administered for12 days, starting on the day of tumor cell inoculation. Tumor-bearing rats showedadipose and muscle mass wasting, body mass loss, anorexia, decreased Aktphosphorylation i Continue reading >>