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Is Lantus A Basal Insulin?

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Diabetes Mellitus Type 1 And Type 2: Insulin Glargine Biosimilar (abasaglar)

In 2 randomised controlled trials (RCTs) insulin glargine biosimilar (Abasaglar) was as effective as insulin glargine (Lantus) at reducing HbA1c levels in people with type 1 and type 2 diabetes. The safety profile of Abasaglar is comparable to that of Lantus. Regulatory status: Insulin glargine biosimilar 100 units/ml (Abasaglar) received a European marketing authorisation in September 2014 and was launched in the UK in September 2015. It is the first biosimilar insulin glargine to be launched in the UK and as part of the licensing process, has been shown not to have any clinically meaningful differences from the originator biological medicine in terms of quality, safety and efficacy. Effectiveness Insulin glargine biosimilar 100 units/ml (Abasaglar) once daily was non‑inferior to insulin glargine 100 units/ml (Lantus) in people with type 1 diabetes (treatment difference 0.11% points [1.18 mmol/mol] p>0.05) for change in HbA1c from baseline (1 open‑label RCT, n=535, 24 weeks). Insulin glargine biosimilar 100 units/ml (Abasaglar) once daily was non‑inferior to insulin glargine 100 units/ml (Lantus) in people with type 2 diabetes (treatment difference 0.05% points [0.57 mmol/mo Continue reading >>

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Popular Questions

  1. Luis65

    Is there a benefit to taking basal insulin in 2 12 hour doses?

    For a month I have had regular hypoglycemic episodes 6 to 8 hours after the nightly dose. When I started regular exercise I would use these lows to adjust the dose. 3 lows in a row equaled a reduction of 2 units. This worked well to go from 85 to 52 units. I was on a plateau for a couple of months. Then I started having lows that were sometimes throughout the day. I reduced to 42 units but I am still having morning lows in the range of 50-60. Daily reading are OK except dinner postprandial which has been in a range of 129 to 191.
    I know that the availability of Lantus is not flat over 24 hours. One chart I found has it peak at 6 hours which would account for me waking up at 3AM with a low. for some people it drops considerably as early as 18 hours. So any here who take basal insulins split the does into two 12 hours apart and what is your experience?
    "Long Acting Insulins (click link for the chart)
    http://www.diabetesnet.com/about-diabetes/ins...
    Though often thought of as being 24 hour insulins, Lantus and Levemir are actually 18 to 26 hour insulins. At least a third of all users do not get a full 24 hours of action from these insulins. Those who experience shorter activity times may also notice more peaking in activity and a tendency to have lower readings about 6 hours after the injection. A larger peak in activity at around 6 hours is usually associated with a shorter action time, and vice versa. Anyone who does not take their long-acting insulin at about the same time each day can also experience gaps and stacking of insulin with a single injection a day. Smaller doses are also often associated with greater insulin activity at 6 hours with less at 18 hours and beyond. More peaking usually indicates less than 24 hours of activity.
    If your Lantus or Levemir “wears out” before the day is done, this can cause unexplained highs before or soon after the time when the next dose is given. It can also cause low readings during its peak activity. For instance, if Lantus is given only at bedtime, night lows may become more likely due to a peak in activity, while if one injection is given in the morning, high readings may occur before breakfast due to the lessening activity from the previous dose.
    Splitting doses of "24 hour" insulins into two equal doses with half taken in the morning and the other half taken in the evening evens out dosing gaps and minimizes peaking. After splitting a single dose of Lantus or Levemir, many people find they have better readings."
    "Benefits of twice-daily injection with insulin glargine: a case report and review of the literature.
    Youssef D1, El Abbassi A, Woodby G, Peiris AN.
    Author information
    Abstract
    http://www.ncbi.nlm.nih.gov/pubmed/20345066
    Insulin Glargine is recommended as a once-daily basal insulin. We report a patient in whom nocturnal administration of Glargine was associated with significant morning hypoglycemia despite titration of insulin dose. Changing the Glargine regimen to morning administration did not result in improvement. However, changing to a twice-daily regimen of Glargine resulted in the resolution of the hypoglycemia. Few studies have addressed the role of multiple daily injections of Glargine and this remains a valuable option in the management of diabetic patients. Prior studies using multiple daily injections with NPH insulin and Ultralente have demonstrated success. We propose that patients with hypoglycemia despite titration of once daily Glargine should be considered for a twice-daily regimen. Despite a slight increase in cost and inconvenience for the patient, the increases frequency of administration may result in a greater success in achieving glycemic targets."

  2. Type1Lou

    When I was on MDI, I only ever took one shot of Lantus per day, but, because of nighttime lows, my endo changed the time from a bedtime shot to a morning shot. But I started pumping insulin in 2011 and hope I never have to return to MDI. Pumping allows for different basal settings throughout the day based on your metabolism and activity level. There is also a temporary basal feature that you can set to give less or more basal insulin in response to specific situations (e.g. fighting illness usually requires more while exercise may require less.) I love this flexibility that you just can't achieve with injections. (I realize this wasn't what you were asking but wanted to respond…hope that's OK.)

  3. Luis65

    I always appreciate what you have to say. I'm going to try spiting the dose starting tonight. I expect to get some highs until my body gets used to the new routine.
    I woke up at 3AM hot and shaky testing 60. I ate a Protein Plus bar and went back to sleep. I woke at 5:30AM 79 before breakfast. I did not test post breakfast but did an easy bike ride and tested 58 pre lunch. Post lunch was 175, Pre dinner 103 and that's where I am now. I did consume some carbs at lunch - 635 cal- 31g carbs, 24g protein, 48g fat.
    I never really keep a food diary before someone here mentioned a really nice phone app called GoMeals. When I loaded it on my phone I have access to it on my computer which is really nice. It has a custom feature for foods that aren't in the Calorie King data base. You can track physical activity, glucose and food. It's the best I've seen.

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