Insulin Vs Testosterone

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Killing Your Sex Drive One Bite At A Time: 5 Surprising Ways Sugar Lowers Libido

Our hormones don’t operate in a vacuum. They are interconnected, performing like a big musical symphony. When one becomes out of balance, others are sure to follow. Sex hormones, healthy blood sugar, and insulin balance are more intimately linked than you might think. Spikes in insulin, and the insulin resistance that results from eating too much sugar and flour, can lead to acne and irregular menstrual cycles and can make women lose hair where they want it and grow hair where they don’t. Men with blood sugar imbalances have trouble getting or maintaining erections and often get “man boobs.” We’ve somehow thought these and other symptoms become normal as we age. They don’t. Libido-crashing mood disorders in women and men reaching for a “little blue pill” do not need to be a part of the aging process. Bad habits such as drinking and smoking, exposure to environmental toxins, and being chronically stressed all diminish sex hormone balance. Yet, the biggest culprit that continually knocks sex hormones out of balance is sugar in all its many forms (including all flour products), which raises insulin and creates a hormonal domino effect. Once you understand how insulin c Continue reading >>

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  1. Manav Batra2


    One third of men with type 2 diabetes(T2D) have hypogonadotropic hypogonadism(HH). Testosterone(T) concentrations are inversely related to BMI. We conducted a randomized placebo controlled trial to evaluate the effect of T replacement on insulin resistance in T2D men with HH.
    50 men with T2D were recruited into the study. HH was defined as free T concentrations <5 ng/dl with normal or low LH and FSH. 26 men had HH(mean total T 247±82ng/dl; free T 4.2±1.1ng/dl) and 24 men had normal total and free T concentrations(means 527±205 and 7.3±2.0ng/dl). Insulin sensitivity was calculated from the glucose infusion rate(GIR) during the last 30 min of a 4 hour hyperinsulinemic-euglycemic clamp(80mU/m2/min) and expressed as mg/kg body weight/min. Lean mass and fat mass were measured by DEXA. Men with HH were randomized to receive intramuscular T(250 mg) or placebo(1ml saline) every 2 weeks for 6 months(n=13 in each group). Clamps and DEXA were repeated at 6 months.
    Men with HH had similar age(54±8 vs. 53±10years, p=0.56) but higher BMI(40±9 vs. 34±7kg/m2, p=0.02) than eugonadal men. Men with HH had higher fat mass(45±15 vs. 34±15kg, p=0.02) but similar lean mass(73±21 vs. 66±9kg, p=0.12) than eugonadal men. Mean GIR was lower in men with HH than in eugonadal men(4.1±2.4 vs. 6.9±3.6 mg/kg/min, p=0.003) even after adjustment for fat mass, lean mass and age(4.6±2.7 vs. 6.4±2.7 mg/kg/min, p=0.05). Total and free T increased after 6 months of T therapy(273±96 vs 561±249 ng/dl, p=0.01; 4.2±1.1 vs. 11.8±7.1 ng/dl, p=0.007; blood sample drawn 1 week after the final T injection) but did not change in placebo group(271±40 vs 349±215 ng/dl, p=0.23; 4.0±0.8 vs. 4.8±2.1 ng/dl, p=0.3). There was no change in weight(123±23 vs 122±24kg, p=0.37) or fat mass(46±15 vs 43±13kg, p=0.24) but lean mass(71±9 vs 72±10kg, p=0.03) increased slightly but significantly after 6 months of T therapy. There was no change in weight(111±38 vs 112±38kg, p=0.85), fat mass(37±16 vs 36±14kg, p=0.19) or lean mass(67±14 vs 67±13kg, p=0.57) in placebo group. GIR increased by 30% after 6 months (4.1±2.0 vs 5.3±2.3 mg/kg/min, p=0.005) of T therapy but did not change in placebo group(3.4±1.5 vs 3.5±1.8 mg/kg/min, p=0.88). Change in GIR did not relate to increase in free T(r=-0.16, p=0.68) or to change in lean mass(r=-0.13, p=0.73) in T group.
    Our data show for the first time that 1) men with T2D and HH are more insulin resistant than those with normal T; 2) insulin resistance is reversed following T replacement.
    Sources of support: NIH
    Nothing to Disclose: SSD, MB, NDK, SS, AC, AM, HG, PD
    *Please take note of The Endocrine Society’s news embargo policy at www.endo-society.org/endo2013/media.cfm

    Sources of Research Support: NIH

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