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Insulin Production

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Cell Factories For Insulin Production

Go to: Introduction The pioneering work of Stanley Cohen and Herbert Boyer, who invented the technique of DNA cloning, signaled the birth of genetic engineering, which allowed genes to transfer among different biological species with ease [1]. Their discovery led to the development of several recombinant proteins with therapeutic applications such as insulin and growth hormone. Genes encoding human insulin and growth hormone were cloned and expressed in E. coli in 1978 and 1979 respectively. The first licensed drug produced using recombinant DNA technology was human insulin, which was developed by Genentech and licensed as well as marketed by Eli Lilly in 1982. There are more than 300 biopharmaceutical products including therapeutic proteins and antibodies in the market with sales exceeding USD100 billion [2,3]. Therapeutic monoclonal antibodies have captured the major market share (>USD18 billion) followed by the hormones (>USD11 billion) and growth factors (>USD10 billion) [4]. Biopharmaceuticals approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) from 2004 to 2013 are largely derived from mammalian cell (56%); E. Coli (24%); S. Cerevisiae (1 Continue reading >>

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Popular Questions

  1. Phyllis Stewart

    Insulin Resistance

    Insulin

    Medicine and Healthcare



    Is there a way or test to find out whether one has insufficient insuline production or insuline resistance problem?




    1 Answer








    Don’t go slurping your urine, for heaven’s sake. Your doctor can order a blood test, called a C-peptide. This test will give an exact measurement of how much insulin your beta cells in your pancreas are making. If there is none, then you are a Type I, insulin-dependent diabetic. Simple. No home test or blood glucose measurement can tell you that.

    28 Views · 1 Upvote








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    Related Questions



    What is insulin resistance?


    What causes insulin resistance?


    Are there tests for insulin resistance?


    Does chromium cure insulin resistance?


    Why does insulin resistance persist?


    What stimulates insulin production?


    Does insulin resistance decrease mTOR signalling from excess insulin?


    Does Clenbuterol reduce insulin resistance?


    Do I have insulin resistance?


    Does Truvada cause insulin resistance?
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