Insulin Negative Feedback Loop

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Homeostasis is the maintenance of a constant internal environment of a cell or an organism, despite fluctuations in the external environment. It has evolved because it gives some organisms a survival advantage. Maintaining a constant body temperature, where enzyme activity is at its optimum level, enables animals to hunt even in freezing conditions. Homeostasis is therefore energy consuming. Some animals prefer not to waste energy maintaining body systems constantly at the ready and reduce their level of activity during cold months by hibernating, such as bears, or remaining dormant as in the case of insects. Homeostasis works by way of feedback mechanisms. Examples include the maintenance of the blood at a specific pH range and body temperature. Systems such as the urinary and respiratory systems work in isolation or in concert to maintain homeostasis. Feedback mechanisms involve: - Receptors in the body that pick up specific changes. this may include heat or blood glucose levels. - A control centre, in most cases it is the brain, that regulates the response. - Effectors, muscles or organs, that are stimulated to cause an effect that corrects the deviation in the internal conditio Continue reading >>

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  1. 7219420

    I'm in an Anatomy and Physiology class this semester (college) and I know this is a basic/key part of everything but for me it's not connecting. I know what homeostasis it- but I start to lose the ability to follow/understand beyond that point. Can someone please help?? /r/explainlikeimfive+askreddit
    EDIT these explanations really helped me get a better grasp of the entire thing. Especially positive feedback!! I really appreciate all the responses and the analogies! My first exam is Thursday (9/4) and I'm hoping I understand this enough to pass!!! Thankyou all!!

  2. [deleted]

    Negative feedback is a system where an input causes something to work against it. A room gets too hot, so a thermostat provides negative feedback to turn the furnace off.
    Positive feedback is a system where an input causes something to work with it. A microphone pics up noise from the speakers, amplifies it and send to the speaker, then picks up the louder noise, and so on until the room is deaf. Global warming melts the ice caps, which then reflects back less sunlight, which heats up the planet more.
    Homeostasis means a system that regulates itself to keep various things stable, like temperature for example. This obviously requires negative feedback to accomplish, while positive feedback is bad for homeostasis as it causes conditions to rapidly change. A thermostat keeping a room the same temperature via negative feedback is homeostasis. In the context of the human body, homeostasis means how your body keeps its self in the same condition, temperature, blood pH, etc. It does this through negative feedback with things like sweating or pH buffers.

  3. KallistiTMP

    Right. Example of negative feedback: blood sugar is high, body releases insulin, sugar is stored as glycogen and fat, blood sugar is no longer high, body stops releasing insulin.
    Positive feedback is much more rare. An example is nausea. Body/brain stimulates nausea, causing stomach contractions, causing more nausea, causing vomiting, causing more nausea, until finally the stomach is emptied. Childbirth and orgasm are also positive feedback systems.

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