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Insulin Like Growth Factor And Diabetes

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The Insulin-like Growth Factor System In Obesity, Insulin Resistance And Type 2 Diabetes Mellitus

The insulin-like growth factor (IGF) system, acting in concert with other hormone axes, is important in normal metabolism. In obesity, the hyperinsulinaemia that accompanies peripheral insulin resistance leads to reduced growth hormone (GH) secretion, while total IGF-I levels are relatively unchanged due to increased hepatic GH sensitivity. IGF-binding protein (IGFBP)-1 levels are suppressed in relation to the increase in insulin levels in obesity and low levels predict the development of type 2 diabetes several years later. Visceral adiposity and hepatic steatosis, along with a chronic inflammation, contribute to the IGF system phenotype in individuals with metabolic syndrome and type 2 diabetes mellitus, including changes in the normal inverse relationship between IGFBP-1 and insulin, with IGFBP-1 concentrations that are inappropriately normal or elevated. The IGF system is implicated in the vascular and other complications of these disorders and is therefore a potential therapeutic target. View Full-Text Continue reading >>

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Popular Questions

  1. JD2109

    Hi this is my first post on here .So has anybody heard anything about research into I.G.F and the claims by an American doctor that this treatment is a cure for diabeties ? Type 1 and type 2 he claims can be cured in a 14 day course of treatment , Also he recons that the large pharmisuitical firms know all about I.G.F but are refusing to back the research because it would cost them millions in lost revenue.

  2. noblehead

    Welcome to the forum
    Never heard of the research, but if there was a known cure available it would be more widely known about by now.

  3. Brunneria

    JD2109 said: ↑
    Hi this is my first post on here .So has anybody heard anything about research into I.G.F and the claims by an American doctor that this treatment is a cure for diabeties ? Type 1 and type 2 he claims can be cured in a 14 day course of treatment , Also he recons that the large pharmisuitical firms know all about I.G.F but are refusing to back the research because it would cost them millions in lost revenue. Yes, we have had a couple of other people appearing with similar queries to your own.
    Unless they produce good quality links (no sales pitch, dodgy claims) and they provide clear, verifiable evidence, I just dismiss it as snake oil salesmanship.

  4. -> Continue reading
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