Insulin Dosing Guidelines Type 1 Diabetes

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Pharmacokinetics Of The Rapid-acting Insulin Analog, Insulin Aspart, In Rats, Dogs, And Pigs, And Pharmacodynamics Of Insulin Aspart In Pigs

The objective of this study was to compare the pharmacokinetics and pharmacodynamics of insulin aspart (IA), a rapidly acting insulin analog, with those of human soluble (regular) insulin (HI) in animal models after s.c. and i.v. dosing. Single doses of IA and HI were administered i.v. and s.c. to rats and dogs at three dose levels, and at one dose level to pigs; rats and dogs also underwent repeated s.c. dosing for 1 week. Plasma insulin levels were assessed at predetermined time points after dosing; plasma glucose levels were measured in pigs only. There were no significant pharmacokinetic differences between IA and HI after a single s.c. or i.v. dose in rats or dogs, and no differences were observed after repeated s.c. dosing, implying there was no accumulation. In pigs, there was a strong trend toward more rapid absorption of IA compared with HI after s.c. dosing, whereas there were no differences after i.v. administration. After s.c. dosing in pigs, IA produced significantly lower plasma glucose levels compared with HI during the period 30 to 75 min after dosing (P < .05). In conclusion, IA was more rapidly absorbed than HI after s.c. administration only in the pig; this diffe Continue reading >>

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Popular Questions

  1. Sub7

    I apologize for bringing up the subject of insulin for the 50th time on these boards, but after reading practically every post on insulin on this site, I am still in the dark as to why (relatively) healthy bodybuilders inject themselves with insulin.
    Yes, insulin shifts substrate utilization towards CHO and is thus protein sparring in the muscle, yes it is anti-catabolic and if anabolism stays the same and catabolism goes down, net protein synthesis will go up and all the other stuff that has been discussed.
    BUT, a non-diabetic's body can manufacture sufficient insulin to even dispose of 10,000 kcal a day without any problems (am I wrong here?). The truth is, bodybuilders do not consume 10,000 calories -and the vast vast majority are not diabetics, at least yet. Even without shooting exogenous insulin, they can utilize the glucose in their bloods. Why, then do they inject themselves with insulin? Would doing so not simply lead the pancreas to down-regulate insulin output and exogenous insulin simply replace endogenous insulin? If such is not the case and you do end up with more insulin in the blood over a 24 hour period by using exogenous administration, would you not end up with more insulin than needed to handle the calories you consume? What would be the advantage of this?
    And, just to clarify what i am talking about; ALL PRO BODYBUILDERS USE EXOGENOUS INSULIN. You can ask how I know this and, sure I have not spoken to all of them, but if you talk to anyone who has been around bodybuilders, it is common knowledge that these guys walk around with a slin pen at all times. There is (almost) no exception to this rule. And these guys grow far larger with insulin, in again, practically every single case... Why? How?

  2. JohnBrinks

    its crazy to me, your body produces enough insulin to cope with whatever you eat otherwise ppl would regularly end up in comas or hypoglycemic after drinking cokeacola.
    IGF-1 would be a far better choice to spend £$ on...

  3. BarbellBeast

    Personally would NEVER use it.
    I use Need2Slin.

  4. -> Continue reading
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