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Effect Of Anti-insulin Antibodies On Glycemic Control In Insulin Treated Diabetic Patients

In order to examine the effect of anti-insulin antibodies on serum insulin concentration and glycemic control, sera from 49 insulin-treated diabetic patients (20 males and 29 females) were examined for their titer of anti-insulin antibodies, and concentrations of total insulin (TIRI), free insulin (FIRI) and hemoglobin A1c. Titer of anti-insulin antibodies correlated only with TIRI (r=0.72, p < 0.001) and did not correlate with duration of insulin treatment, FIRI concentration, daily dose of insulin, or HbA1c concentration. These results indicate that elevated titer of anti-insulin antibodies in patients under insulin therapy, (1) increases total serum insulin concentration but does not affect serum free insulin level, and (2) has little effect, if any, on glycemic control and the required daily dose of insulin. Continue reading >>

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Popular Questions

  1. Haze66

    Can you spare some insulin ( novalin 70/30 and or Humalog regular insulin and Lantus)

    I'm in Savannah, Tennessee. I just traveled here from California and lost my insulin on the way. I was hopin somebody might have some to spare or purchase for cheap. If you know someone who does or information on where i can get help. I have little money and no health insurance. I am a 25 year old white male from California. I was diagnosed with type 1 4 years ago.

  2. Gomer

    I suggest you head to the local hospital/ER ASAP. They should be able to direct you to a clinic at the hospital, county health dept or similar. NPH, also called just 'N' and regular insulins are OTC and last I hear, about $25/vial each. The NPH/N does not last as long as Lantus. Most likely, as a T-1, you will NEED insulin long before anyone could somehow send you some.
    When I lost my job and we became homeless, in Orlando I would go to the county health dept and they would give me my insulin there, I had no way to keep it cool anyway.

  3. furball64801

    Hi and welcome to DD I would suggest a hospital or clinic if I was anywhere near you of course I would share insulin. It would be good to post what type you use and last resort is walmart has otc insulin for about $25 good luck in your search.

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