How Many Amino Acids Are There In Insulin?

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Structure And Function Of The Insulin Receptor

INTRODUCTION Insulin initiates its cellular responses by binding to its cellular receptor, a transmembrane, multi-subunit glycoprotein that contains insulin-stimulated tyrosine kinase activity [1]. The cellular content of insulin receptors is variable, with the highest level of expression in cells that are most responsive to insulin for glucose, lipid, and protein metabolism, especially adipose, skeletal muscle, and liver. Initially identified over 25 years ago [2], the insulin receptor cDNA was cloned in 1985 [3,4]. Crystal structures of its protein tyrosine and of its extracellular domains were determined in 1994 [5] and 2006 [6], respectively. Since insulin has profound importance in metabolic control, studies of its receptor protein have been the subject of intense investigation [7]. EXPRESSION AND SUBUNIT STRUCTURE Receptor gene and mRNA — The insulin receptor gene maps to human chromosome 19 and spans more than 150 kilobases (kb) [8]. The 22 exons of the receptor gene are transcribed into several mRNA species ranging from 4.2 to 9.5 kb in length due to variation in their 3'-untranslated regions [9]. Exon 11, which encodes a 12 amino acid segment localized to the C-terminus Continue reading >>

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Popular Questions

  1. K. M.

    How many amino acids do the insulin protein of apes and chimanpzees compose of?!

  2. alec_djinn

    On the Ensembl website you can find an easy way to compare genetic sequences of the available genome references, including the one of several primates.
    Here a query example: http://www.ensembl.org/Homo_sapiens/Gene/Compara_Alignments?align=822&db=core&g=ENSG00000254647&r=11%3A2159779-2161341
    For protein sequences, check the Uniprot website. For insulin, this is the page you are looking for http://www.uniprot.org/uniprot/P01308 Check the paragraph "Similar proteins", there you will find all the links to retreive the insulin sequence from all the species for which we have sequencing data.

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