How Many Amino Acids Are There In Insulin?

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Amino Acids, Glucose Metabolism And Clinical Relevance For Phenylketonuria Management

Abstract It is general knowledge that glycaemia is affected by digested nutrients. Amino acids intake appears to be an important regulator in this regard. Many questions need to be answered, such as the real mediators of this response and the mechanisms underlying this metabolic behavior. Studies have been undertaken in order to investigate the role of amino acids on metabolic parameters. Their main findings suggest that the ingestion of free amino acids have a pivotal role in avoiding glycaemia excursions, improving glucose tolerance. In parallel, several important molecules for glucose metabolism have been exploited. Insulin and glucagon-like peptide – 1 (GLP-1) release seem to be the main triggers of this response. This insulinogenic effect is attributed to some amino acids, particularly the branched-chain amino acids (leucine, isoleucine and valine). GLP-1 may exert its effects by activating its receptor in pancreas and enhancing insulin release by β-cells or through its extrapancreatic actions. The mechanisms that may justify the aforementioned effects remain to be answered, being the mTOR pathway activation a possible key. These metabolic effects may have a special interes Continue reading >>

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Popular Questions

  1. K. M.

    How many amino acids do the insulin protein of apes and chimanpzees compose of?!

  2. alec_djinn

    On the Ensembl website you can find an easy way to compare genetic sequences of the available genome references, including the one of several primates.
    Here a query example: http://www.ensembl.org/Homo_sapiens/Gene/Compara_Alignments?align=822&db=core&g=ENSG00000254647&r=11%3A2159779-2161341
    For protein sequences, check the Uniprot website. For insulin, this is the page you are looking for http://www.uniprot.org/uniprot/P01308 Check the paragraph "Similar proteins", there you will find all the links to retreive the insulin sequence from all the species for which we have sequencing data.

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