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How Is Synthetic Insulin Made

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How Is Synthetic Insulin Made?

Synthetic insulin was first made in 1978 by scientists at Genetech, Inc. and City of Hope National Medical Center. This achievement was a giant step forward in insulin production for people with diabetes. Previously, pig and cattle pancreas glands were the only viable method of production. While sufficient for most diabetics, the use of animals to produce insulin did cause some allergic reactions, as it was not a true human match to insulin. Scientists use recombinant DNA gene technology to synthesize insulin. Insulin is composed of two amino acid chains that are joined together. The “A” chain has 21 amino acids, while the “B” chain has 30. These amino acid chains have a specific order. The process is somewhat complicated so the following is an excerpt from the Genetech press release explaining the actual scientific process: Insulin is a protein hormone composed of two chains of amino acids: an “A” chain and a “B” chain linked together by two disulfide bonds. The “A” chain is composed of 21 amino acids and the “B” chain of 30 amino acids, each arranged in a uniquely ordered sequence. Proteins are made by translating the genetic information which is carried i Continue reading >>

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  1. Crashnot

    Synthetic Insulin Side Effects

    I just posted this info on a post I made earlier today about not feeling well.
    But after Googling "Synthetic Insulin Side Effects" I got an education and wanted to pass it along on a separate post.
    This is nasty stuff and getting worse! As the patents run out on the original synthetic insulins, they are coming out with "analog" versions that are troublesome.
    For those of you who have wondered about being MOODY, DEPRESSED, CONFUSED, have unexplained Aches and Pains, feel unwell for no reason, or LETHARGIC, please read this report and do your own Googling.
    I am in the process of getting a vial of the pork insulin from the lab in the report. It is still being produced in the UK and is available in Canada and most likely the US. I hope to recover my energy and mental alertness just as quickly as I did when I quit using first Lantus and then Levemir.
    Hopefully these problems do not affect you, but better to be aware than floating around like a zombie as I am.
    I might be remembering wrong, since my mind has been mush for a few years (about as long as I've been using Humalog, actually), but I think it said the synthetic effects about 10% of users. That's a lot in my book!
    Here is the best link I found:
    http://www.iddt.org/wp-content/uploads/2009/1...
    Lisa

  2. Crashnot

    Julie, sounds like we're swimming for the same boat! I've been labeled "brittle" for years and am pretty unaware of when my sugars are dropping. I was told it's just because I've been diabetic for so long and my nerves have been damaged. But I have no feet, kidney or eye damage. Hmmm?
    I have already gotten an email back from the Canadian company that distributes the porcine insulin and I can get it by special order from any pharmacy in Canada. The downpoint? Looks like it is about $125 a vial.
    She is not sure if it is stable at body temp for the pump, and will let me know when she is back in the office next week. I will let you know! I'm half hoping it's not suitable for the pump. As convenient as it is, it's a hassle too!

  3. Crashnot

    Julie, sounds like we're swimming for the same boat! I've been labeled "brittle" for years and am pretty unaware of when my sugars are dropping. I was told it's just because I've been diabetic for so long and my nerves have been damaged. But I have no feet, kidney or eye damage. Hmmm?
    I have already gotten an email back from the Canadian company that distributes the porcine insulin and I can get it by special order from any pharmacy in Canada. The downpoint? Looks like it is about $125 a vial.
    She is not sure if it is stable at body temp for the pump, and will let me know when she is back in the office next week. I will let you know! I'm half hoping it's not suitable for the pump. As convenient as it is, it's a hassle too!

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