How Is Insulin Metabolized

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Pvhl Is A Regulator Of Glucose Metabolism And Insulin Secretion In Pancreatic Β Cells

During adulthood, cell type-specific growth that exceeds the normal physiological constraints is a common feature of adaptive processes of tissues to changes in metabolic homeostasis and underlies the development of many human diseases, including cancer, heart disease, and diabetes (De Boer et al. 2003; Bouwens and Rooman 2005). Adaptive cell mass expansion, whether neoplastic or nonneoplastic, creates a requirement for compensatory neovascularization to supply oxygen, metabolic substances, and growth/survival factors to the growing tissue (Marti 2005). Therefore, adaptive cell growth responses are generally accompanied, at least initially, by relative states of hypoxia as a result of a mismatch between oxygen demand caused by tissue expansion and oxygen supply provided by the vasculature. An immediate consequence of decreased tissue oxygen availability is that cells shift cellular fuel metabolism from mitochondrial respiration to glycolysis and activate an angiogenic program to increase oxygen delivery in order to overcome the imbalance between tissue mass and vascularization (Semenza 2001; Brahimi-Horn et al. 2007). In this way, tissue function is supported and further mass expan Continue reading >>

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Popular Questions

  1. clackley

    Hello. I am a Canadian and recently had a fasting insulin test done and don't know how to interpret the results considering I have been keto for more than 7 yrs.. My results tells me info in 'pmol/L'. Any one know how to convert that or what I should hope to have in the method of measurement! Thanks in advance for any help you can give me.

  2. richard

    Divide pmol/l by 6 to get mU/l.
    The normal Physiological range for fasting insulin is 4mU/l to 13 mU/l.
    I have 19.8 mU/l which is horrible.
    Why it's important is because when you are fasted you should be burning body fat for energy. Insulin inhibits lipolysis (body fat burning). You can see that on this chart, and work out where your own fasting level puts you at.

  3. Barbara_Greenwood

    I'm considering having mine tested - my doc won't be interested, I'm sure, I'll have to pay privately, but I've found somewhere that does it for £39, so not a big problem. I've been T2D for 19 years and been keto for 7 months - last HbA1C was 40 (5.8%) in November, down from 62 (7.8%) in August, and my BG is now in the normal range most of the time. I'd love to see how my insulin is doing, and I've been wondering how often it makes sense to check it. What do you think?

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