Glucagon And Insulin Are Antagonists Of Each Other Justify The Statement

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Insulin And Glucagon:

Please log in to add your comment. Transcript of Insulin and Glucagon: Effect: Glucagon A polypeptide hormone secreted by alpha cells that initiates a rise in blood sugar levels by stimulating the breakdown of glycogen by the liver. Animal or Plant Hormones? Insulin and Glucagon are animal hormones. Target Tissues Insulin: Liver, Muscles, Adipose Glucagon Liver, Skeletal Muscles, Adipose A Little Bit About Type 1 Diabetes RECAP Insulin and Glucagon: What is being controlled ? Blood glucose (C6H12O6) is being controlled by the body with the interactions of insulin and glucagon. Antagonistic , Synergistic, or Neither? Insulin and Glucagon are antagonistic hormones since glucagon creates a rise in blood glucose and insulin lowers the blood glucose. Release Origin Insulin: Pancreas: islet cells (beta cells derived from murine embryonic cells) Glucagon Pancreas: islet cells of Langerhans Effect: insulin Like the receptors for other protein hormones, the receptor for insulin is embedded in the plasma membrane. The insulin receptor is composed of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha chains are entirely extracellular and house insulin binding domain Continue reading >>

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  1. ForEverYoung

    Originally Posted by Stump86
    I don't think insulin is a direct input to the pancreas. There is nothing in the pancreas that says "the insulin level is X." But does the pancreas produce more glucagon when insulin levels are low and more insulin when glucagon levels are low, absolutely. That doesn't make sense. If that were the case then it would be in all the medical books, what you're talking about would have profound effects on bg levels and the medical community would mention it.
    If that were the case then if a person lost phase one response or there was not enough insulin to bring bg down after a big meal you would get a spike after phase 1 or phase 2 response (after all the food was digested). You pancreas would go into positive feedback.

    Does the liver respond to low levels of insulin one way and high levels of insulin another way, absolutely not. I think that is the question/comment with which you started the thread, no?

    I think it does, for two reasons:
    1) There are many cells in the liver, when insulin runs low, some cells will get an insulin input other won't and would be subject to the slightest stress hormone. So as insulin levels go low, not all liver cells would be turned off to producing glucose.
    2) In the presence insulin resistance the effect is more pronounced, since less cells get an insulin "turn off " signal at a lower amount of insulin, keep in mind that in the presense of insulin resistance you need more insulin to generate a "Turn Off" signal. That is why some people have to a larger amount of insulin to turn the liver off.
    So when insulin is low, some of the cells are getting a "turn on signal" and some are getting a "turn off signal", that is supported by the fact that again, that some people have to take a large amount of insulin to FULLY TURN OFF THE LIVER.
    If low levels of insulin caused the pancreas produce large amounts of glucogen to be generated then you would see large amount of glucogen with morning DP, most of those hormones are stress hormones.
    Oh and I forgot to mention, the liver does respond to low levels of insulin one way andl high levels another in the presense of insulin resistance. By definition when you are inuslin resistant you need more insulin to do the same work. It's like needing more current to get the same brightness out of a light bulb.

  2. dlabbee

    Here is an explanation of how the pancreas works. http://www.mydr.com.au/gastrointesti...as-and-insulin

  3. furball64801

    Originally Posted by dlabbee
    Here is an explanation of how the pancreas works. http://www.mydr.com.au/gastrointesti...as-and-insulin Thanks for the link it explains it very well.

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