Exercise Insulin Sensitivity Mechanism

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Ogtt-derived Measures Of Insulin Sensitivity Are Confounded By Factors Other Than Insulin Sensitivity Itself Katrin Hã¼cking

University of Pennsylvania ScholarlyCommons Departmental Papers (Vet) School of Veterinary Medicine Darko Stefanovski University of Pennsylvania, [email protected] Richard N. Bergman Follow this and additional works at: Part of the Endocrinology, Diabetes, and Metabolism Commons At the time of publication, author Darko Stefanovski was affiliated with the Keck School of Medicine at the University of Southern California. Currently, he is a faculty member at the University of Pennsylvania's School of Veterinary Medicine. This paper is posted at ScholarlyCommons. For more information, please contact [email protected] Recommended Citation Hücking, K., Watanabe, R. M., Stefanovski, D., & Bergman, R. N. (2012). OGTT-Derived Measures of Insulin Sensitivity Are Confounded by Factors Other Than Insulin Sensitivity Itself. Obesity: A Research Journal, 16 (8), 1938-1945. 10.1038/oby.2008.336 OGTT-Derived Measures of Insulin Sensitivity Are Confounded by Factors Other Than Insulin Sensitivity Itself Abstract Insulin resistance is an important risk factor for diabetes and other diseases. It has been important to estimate insulin resistance in epidemiological and genetic st Continue reading >>

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Popular Questions

  1. feejee

    Not diabetes related, but i thought people here would have excellent knowledge with this sort of thing.
    When i was in hospital before christmas they gave me injections of a blood-thinner into my stomach each day (everyone in bed had to have it to avoid clots). One of the jabs left me with quite a big bruise appear on the stomach near the injection site, which has now gone, but im left with quite a hard lump a couple of cm under my skin/flab. Is there anythng i can do about this, will it just go eventually, or do they stay forever?
    The thing that concerns me is if i got this lump from only a few days injections, when (if) it comes my time to start using insulin am i likely to become full of hard lumps whereever i inject?

  2. Liam

    When I was a kid / teen I would inject into the same spot all the time. This caused large lumps of hard fat, much bigger than you have got. I finally saw the light and started moving my injections around and the lumps have gone.
    I don't think you can really say just because the anti-clot agents caused a lump than insulin would do the same. Insulin tends to be used in small amounts, uses small thin needles (needles used to draw up medication are thicker so they don't bend going into the vial)
    I can't say for sure if it will go away but mine did. Same people think massaging the area helps but I think time is the real answer.

  3. nytquill17

    I don't know anything about blood thinners, how they are injected, etc. I wonder if you might not have a bit of scar tissue if it bruised that badly? I get bruises off insulin injections from time to time but since it's just a tiny needle (4mm) it's mostly just the little capillaries right under the skin and not really a big deal (doesn't scar underneath). If the blood thinners were done with a big needle or perhaps by someone really incompetent the time that it bruised maybe there was some actual damage to the tissues under the skin that scarred over? It would be worth asking about next time you see a doctor maybe.
    You could try a bit of heat and massage, see if that doesn't "encourage" it to dissipate - I don't know that it will but it's what I would try in your shoes!
    As to insulin - I have been injecting it for 17+ years, others on here much longer than me. I know Sedge has some lipos (lipodistrophy which is the "umbrella" name for this type of issue - hypertrophy when it lumps up and hypotrophy when it hollows out) but she was on the scene a long time before I was back when the injection equipment was nowhere near as good (boiling and reusing the same syringes over and over!) and caused a lot more damage to the skin, as did some of the insulins themselves at the time (animal insuilns). Now the needles are very small and disposable, and insulin is mostly synthetic so you don't get the same reactions to it. Animal insulins are still available and handy for people (like our member Sue who pops in now and again) who for whatever reason can't use synthetic insulins (allergies or it just doesn't work right for them) but even so I think they are processed better now so they are less likely to cause lipos than they were in the past.
    The main things that contribute to scarring from injections are: injecting repeatedly in the same area (within an inch or two let's say) and using dull needles (that is, reusing needles multiple times, since on the first use they are very sharp and smooth but they become dull and ragged, microscopically, with even just one use) because they cause more damage to the surrounding tissue which encourages the body to react differently to that injection site than to one from a sharp needle. So as long as you have good practices about your injections, always using a new needle and rotating your injection sites, you shouldn't have any scarring at all.
    I haven't always been the best rotator of sites and for a long time I re-used needles (question of cost since I was paying out of pocket) and I've had no lipos - I'm not saying you should do what I did! In fact definitely don't. But my point is that if I started out breaking the rules for a while and still came out okay, then someone who starts out doing it properly from the very beginning should have ZERO issues whatsoever

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