Why Are People With Diabetes Prone To Developing Chronic Wounds?
Wound Healing in Diabetes The diabetic ulcer is an excellent example of how multiple physiologic and biochemical defects can lead to impaired wound healing. Fifteen percent of patients suffering from DM will suffer a foot ulcer in their lifetime. Patients with DM show a 5-50 fold higher risk of non-traumatic amputation compared with non-diabetic individuals. Nearly 50% of all non-traumatic lower extremity amputations performed in the US are due to DM. The reasons for poor wound healing in DM are many and varied. Diabetic foot ulcers are often caused by repetitive mechanical stress, unrecognised by the patient because of peripheral neuropathy and loss of protective sensation. In addition, the presence of peripheral vascular disease and infection can lead to poor healing of foot wounds and to the development of gangrene. An acute wound in a diabetic patient or a constant and persistent level of trauma, may lead to the development of one of these troublesome wounds. Chronic wounds appear to become “stuck” in the inflammatory and proliferative phases of wound healing. This allows for repeated injury, infection and inflammation. All of this impairs full wound closure. There Continue reading >>