What Diabetes Medications Are Linked To Amputations

Share on facebook

Fda Orders Stronger Warning About Canagliflozin (invokana) & Amputation Risk

The U.S. Food and Drug Adminstration is calling attention to the risk of amputation if you're on the drug canagliflozin (Invokana, Invokamet). It is requiring the drug to carry stronger warnings about the risk. The drug's label will have the so-called ''black box'' warning, designed to call attention to serious or life-threatening risks.1,2 The decision, announced May 16, was not unexpected, says J. Michael Gonzalez-Campoy, MD, PhD, FACE, medical director and CEO of the Minnesota Center for Obesity, Metabolism and Endocrinology and a member of the editorial board for EndocrineWeb. The recent decision was issued as an update to a 2016 safety alert. "In May, 2016, the FDA called attention to one trial (CANVAS, or CANagliflozin cardioVascular Assessment Study) in which the incidence of amputations was higher among people taking the medication compared to people taking placebo," Dr. Gonzalez-Campoy says.3 The risks were twice as high in those treated with the drug. Over a year's time, the amputation risks were evaluated to be 7 of every 1,000 treated with 100 milligrams of the drug, versus 3 of every 1,000 on placebo.3 A second trial also identified a higher risk of amputation with the Continue reading >>

Share on facebook

Popular Questions

  1. Anonymous

    How much harm certain individuals - really bad people - can wreak.
    These people are called psychopaths.
    Narcissists are also bad people, but not nearly as bad as psychopaths.
    If only people understood what these people were capable of, I think we would have the understanding that would allow us to come up with much better ways to "fight injustice" or whatever people want to call it - because these people comprise such a large proportion of what's called "injustice." I would also hope that understanding psychopathy and narcissism would lead us to stop calling all atrocities "injustice," because that implies some sort of "reasonable" base. Psychopaths and narcissists are not reasonable people - they just require us to figure out how to defend ourselves against them, or to collectively take away their power. (There is no hoping they will change - unless they change on the surface after we take away their power.)
    See this answer for more info
    Anonymous' answer to Why do certain people derive pleasure from doing cruel things to their fellow human beings?
    P.S. I would hope that liberals would stop thinking of all problems as "systemic" and rooted in "ideas." That is so wrong. Systems and ideas might comprise a small fraction of the worst suffering in the world. But look at individual cases of the worst "injustice" - I would guess most are rooted in the cause of really bad individual people. The "systems" and "ideas" support bad people in power, rather than fighting bad people.
    Really interesting, ironically, the "idea" that all problems are "systemic" and rooted in "ideas" - is probably an "idea" that supports really bad individual people, rather than targeting really bad individual people for who they are and their effects on others, and toppling them from power.
    P.P.S. If you want to learn more about psychopathy, check out Jon Ronson's The Psychopath Test, and the work of Bob Hare. Books I haven't read but heard are informative are Bob Hare's Snakes in Suits (corporate psychopathy), and Martha Stout's The Sociopath Next Door.
    Please, everyone, learn more!!

  2. -> Continue reading
read more close

Related Articles

  • What Diabetes Medications Are Linked To Amputations

    Canagliflozin tied to a doubling of amputations of legs, feet, agency says WEDNESDAY, May 17, 2017 (HealthDay News) -- The type 2 diabetes prescription drug canagliflozin (brand names Invokana, Invokamet, Invokamet XR) appears to increase the risk of leg and foot amputations, the U.S. Food and Drug Administration says. The FDA is requiring the medications to carry new warnings about the risk. The required warnings on the drug's labeling include t ...

    diabetes Jan 2, 2018
  • Why Do Diabetes Cause Amputations

    Blood vessel and nerve damage linked with diabetes can lead to serious infections that are extremely hard to treat. Often the first place you have a problem is your feet. When you lose the ability to feel your toes and feet, you are more likely to injure them without knowing it. Even a minor injury, such as a small cut, can develop into an ulcer and a serious infection. Infections of the feet can spread up into the leg. Sometimes the infection is ...

    diabetes Dec 30, 2017
  • Diabetes Medication And Amputations

    A link has been found between a type 2 diabetes drug and a higher risk of amputation, research has shown. Scientists discovered a link between the usage of NICE-recommended canagliflozin to treat the condition and an increase in lower-limb amputations. As a result of the findings, GPs may now consider stopping the use of the drug in people with diabetes with foot problems, the European Medicines Agency (EMA) has said. The EMA announced it will re ...

    diabetes Jan 4, 2018
  • Metformin Amputations

    Type 1 diabetes results from a rheumatoid-like autoimmune reaction in which one’s own body attacks and destroys the beta cells of the pancreas. These are the cells that normally produce insulin. Type 1 is a disease in which the patient in a relatively short time has no insulin production. All patients with type 1 diabetes can also develop a serious metabolic disorder called ketoacidosis when their blood sugars are high and there is not enough i ...

    diabetes Jan 4, 2018
  • How Is Diabetes Linked With Homeostasis

    Homeostasis is the tendency to resist change in order to maintain a stable, relatively constant internal environment. Homeostasis typically involves negative feedback loops that counteract changes of various properties from their target values, known as set points. In contrast to negative feedback loops, positive feedback loops amplify their initiating stimuli, in other words, they move the system away from its starting state. What's the temperat ...

    diabetes Jan 3, 2018
  • How Is Diabetes Linked With Homeostasis Course Hero

    A pathology often contributing to homeostatic imbalance is diabetes mellitus, a condition that results from either the over-production or, in some cases, the hyper-activity, of the hormone insulin. When no homeostatic imbalance is present, the body is able to regulate its blood sugar levels efficiently. When diabetes mellitus is present, however, after a person has eaten a meal, the insulin needed for regulation is either totally absent or presen ...

    diabetes Jan 4, 2018

Popular Articles

More in diabetes

Whoops, looks like something went wrong.