Sudden Onset Type 1 Diabetes Adults

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Sudden Onset Of Diabetes In Previously Healthy Female.

Did your sister have an infection - flu or diarrhoea preceding the diabetes? It can as far back as 6 months precious. Some patients do not recover from the infection and develop immune disturbances which can trigger autoimmune diseases, especially if there is a lack of vitamin D. Even a simole traveller's diarrhoea can do this since GLP-1 is produced and released from the distal part of the small intestine. GLP-1 in turn regulates the apoptosis of pancreatic beta cell as well as the production of beta cells from stem cells. Pancreatic beta cells have a high turnover rate and if there is a lack of gastrin, GLP-1 or other incretins released from the L and K cell of the intestinal tract, production of new cell may be slower than the apoptotic rate. Any inflammation of infection will increase the beta cell destruction and result can be type 1 diabetes at any age. An easy way to check whether it is type one or two is to check the level of C-peptide. If this is very low it means insulin release from beta cells is low since one molecule of C-peptide is released with each molecule of insulin. If insulin level and C-peptide are high then there is a problem of insulin resistance ie. insulin Continue reading >>

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  1. DiabeticDani

    So, I don't know how rare I am to be diagnosed with Type 1 at age 28, but I feel like an oddity. I was diagnosed at the end of June of this year, purely by luck after requesting routine labwork of my NP after a routine visit with her.
    Three years ago, based on my fasting blood sugar, I was told I was pre-diabetic and asked to lose weight and have an A1C. I lost some weight and my A1C back then was 5.6, so I was made to believe I would be okay.
    I really hadn't given diabetes much thought since that visit three years ago, but decided in June it was time to be reevaluated. Well, my first fasting bg was over 400, followed by my new A1C level at 11.7, followed by a repeat fasting on a different day in the 200's. Bam, now I have diabetes.
    I was extremely fortunate and swiped a canceled appt with an endocrinologist. Only in retrospect did I have DM symptoms, I was getting up multiple times most nights to urinate or chug liquids, I was sometimes ravenously hungry, and I was always sweating profusely and tired constantly.
    At my initial endocrinologist visit, I was put on nightly Lantus and they did a GAD antibody test, being that those are the most common in Type 1. It felt like forever (was really like a week to a week and a half) until my test came back, highly positive for GAD autoantibodies. Normal is 1-5, mine was nearly 800 (although I have been told a high number doesn't really mean much). So, after that test came back, Humalog got added in a dinnertime, and within a week or so, I started dosing at all meals, but never snacks.

    My question is, everything I have read about LADA suggests that it is slow to progress and that people with it don't need insulin right away, so does that mean that more than likely, I do not have LADA? I know it is just for academic purposes and doesn't change my treatment, but I am still trying to wrap my head around this diagnosis. Also, I have not had a c-peptide nor other antibody testing and wonder how valuable that information is or has been to any of you? Thanks!

  2. Brian_BSC

    Many people believe that LADA is just an adult form of slow onset T1. Nothing more. Maybe our adult immune systems are more robust and resilient against the autoimmune attack and the who process is just slower who knows. But some people have a fast onset and others have a slow onset. Some with LADA can go more than a decade before needing insulin. And it isn't just the autoimmune attack. When your blood sugar gets high (like yours did), the high blood sugar actual kills your beta cells (this is called glucotoxicity). To it isn't uncommon even for people with T2 to have very high blood sugars and see a sudden onset of diabetes that ends them up in the ER. Some people find that once they normalize their blood sugars their beta cells can perhaps partially heal from the glucotoxicity and if that is the case you may experience a honeymoon.
    Maybe, maybe not. And a honeymoon isn't always fun since it can make you diabetes quite unpredictable.
    ps. There is no test for LADA, only a test for T1. If you recover and need less insulin you will see it.

    pps. A positive antibody test on any one of the antibodies is sufficient for a T1 diagnosis. You will probably get a c-peptide, but it isn't like to change your diagnosis or treatment unless you insulin requirements dramatically change.

  3. MarieB

    gosh @DiabeticDani sorry to welcome you to the club nobody wants to join. I think some LADAs can be rapid onset, like @Melitta here has written about
    Rapid onset Type 1 diabetes in adults
    Type 1 and LADA
    Hi: As many of you know, I write a lot of blogs on misdiagnosis of adult-onset Type 1 diabetes (adults with new-onset T1D who are misdiagnosed as having Type 2 diabetes, based on age not etiology). Here is a link to one of my blogs. I am in the process of writing a new blog about new-onset T1D in adults that is rapid onset (not slow onset like LADA), and wanted to hear from others about their experiences when first diagnosed. How were you diagnosed? Were you correctly diagnosd? Were there any re…

    I don't think the general public knows very much about how common it is for adults to be diagnosed with type1. Our community was founded by @askmanny who was dx in his 30s, and his doctor was sure he was type2 at first. the most common thing to happen with LADAs is to be originally misdx as a type2, sometimes for years. Maybe it's a small blessing this didn't happen to you. Welcome to the community.

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