Rheumatoid Arthritis And Diabetes Type 1

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Disease-specific And Common Hla And Non-hla Genetic Markers In Susceptibility To Rheumatoid Arthritis, Type 1 Diabetes Mellitus And Multiple Sclerosis

No. Abbreviated gene name Full gene name Function of the protein Associated diseases 1. PTPN22 Protein tyrosine phosphate An inhibitor of T-cell activation, contributes to signaling cascades (TLR, TCR, BCR pathways) initiated in immune cells, including B cells and cells of the innate immune system. RA, systemic lupus erythematosus (SLE), T1DM, Hashimoto disease (HD), Graves’disease (GD), vitiligo [53] 2. STAT 4 Signal transducer and activators of transcription 4 Part of the JAK-STAT signalling pathway, expressed only spermatozoa, myeloid cells, and T lymphocytes. STAT 4 is activated by tyrosine phosphorylation in response to interleukin-12 (IL-12) treatment of T cells, involved in T helper cell function. RA, SLE, Sjögren’s syndrome, juvenile idiopathic arthritis (JIA), GD, myasthenia gravis [54,55] 3. CTLA-4 Cytotoxic T-lymphocyte antigen-4 Cell surface molecule involved in the regulation of signaling pathways affecting T-cell responses. Activation results in decreased T-lymphocyte activity and regulates the immune response. RA, SLE, T1DM, Addison’s disease (AD), Vitiligo, MS, HD[56,57] 4. TRAF1/C5 Tumor necrosis factor-receptor associated factor 1/complement component 5 loc Continue reading >>

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Popular Questions

  1. becci

    Type 1 & Rheumatoid arthritis

    In Feb. 1987 I was diagnosed with type 1 and then in Sept. 1987 I was diagnosed with Rheumatiod. Yesterday I had a flare up of the RA and started taking Prednizone. It always shoots my blood sugars so high I can't get a handle on it. I eat nothing and use 50% more insulin and my sugars are still close to 400. Does anyone here have any ideas on how to fix this?

  2. furball64801

    I know of many that have had this issue with the med, it shoots me high too. I use a lot more water and more insulin, it will run its course.

  3. Nan OH

    Very sorry that you have the added pain of RA. I know two people who are T1 and also have RA. They eat somewhere in the 80-120 grams of carbohydrates a day and have some form of protein at every meal, they also drink lots of water. They also take what ever insulin is needed to help drive their Blood Glucose Level down but keep food and drink handy in case they experience an unexpected low.

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